Title: Structure of native leukocyte myeloperoxidase in complex with a truncated version (SPIN truncated) of the Staphyloccal Peroxidase Inhibitor SPIN from Staphylococcus aureus
Keywords: Oxidoreductase, protein inhibitor, Complex
Source: Homo sapiens, Staphylococcus aureus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.28Å
Release date: 2022-10-26
Entity 1: Myeloperoxidase light chain
Strand: A,C,G,I,M,O,S,U
Type: polymer
Polymer type: polypeptide(L)
Fragment: UNP RESIDUES 167-271
Source: Homo sapiens (Taxonomy ID:
9606)
Entity 2: Myeloperoxidase heavy chain
Strand: B,D,H,J,N,P,T,V
Type: polymer
Polymer type: polypeptide(L)
Source: Homo sapiens (Taxonomy ID:
9606)
Entity 3: Myeloperoxidase inhibitor SPIN
Strand: E,F,K,L,Q,R,W,X
Type: polymer
Polymer type: polypeptide(L)
Source: Staphylococcus aureus (Taxonomy ID:
1280)
Expression system: Escherichia coli
Source gene: spn, KMZ21_01875
Entity 10: CHLORIDE ION
Type: non-polymer
Entity 11: HEME C
Type: non-polymer
Entity 12: CALCIUM ION
Type: non-polymer
Entity 13: 1,2-ETHANEDIOL
Type: non-polymer
Entity 14: 2-acetamido-2-deoxy-beta-D-glucopyranose
Type: non-polymer
Entity 15: ACETATE ION
Type: non-polymer
Entity 16: OXALATE ION
Type: non-polymer
Entity 17: water
Type: water
Entity 4: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 5: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 6: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 7: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 8: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 9: alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Structure entry #551: N-Glycan fragment GlcNAc2Man1 [5 instances]
b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #231: M2 N-glycan linked to Asn [1 instances]
a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #2026 [8 instances]
a-L-Fucp-(1-6)+
|
a-D-Manp-(1-6)+ b-D-GlcpNAc-(1-4)-Asn
| |
b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)+
|
a-D-Manp-(1-3)+
Structure entry #548: N-Glycan fragment GlcNAc2 [6 instances]
b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #1516 [1 instances]
a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #1517: N-Glycan core structure linked to Asn [1 instances]
a-D-Manp-(1-6)+
|
b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
|
a-D-Manp-(1-3)+
Structure entry #229: N-Glycan fragment GlcNAc1 [4 instances]
b-D-GlcpNAc-(1-4)-Asn