Title: Crystal structure of the receptor binding domain of SARS-CoV-2 Omicron BA.4/5 variant spike protein in complex with its receptor ACE2
Keywords: Spike protein, Receptor, Coronavirus, VIRAL PROTEIN
Source: Homo sapiens, Severe acute respiratory syndrome coronavirus 2
Experimental method: X-RAY DIFFRACTION
Resolution: 3.36Å
Release date: 2022-09-28
Entity 1: Processed angiotensin-converting enzyme 2
Strand: A,C
Type: polymer
Polymer type: polypeptide(L)
Source: Homo sapiens (Taxonomy ID:
9606)
Expression system: Homo sapiens
Source gene: ACE2, UNQ868/PRO1885
Entity 2: Spike protein S1
Strand: B,D
Type: polymer
Polymer type: polypeptide(L)
Source: Severe acute respiratory syndrome coronavirus 2 (Taxonomy ID:
2697049)
Expression system: Homo sapiens
Source gene: S, 2
Entity 3: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 4: beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 5: alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 6: alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Type: branched
Entity 7: ZINC ION
Type: non-polymer
Entity 8: 2-acetamido-2-deoxy-beta-D-glucopyranose
Type: non-polymer
Structure entry #548: N-Glycan fragment GlcNAc2 [3 instances]
b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #551: N-Glycan fragment GlcNAc2Man1 [3 instances]
b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #231: M2 N-glycan linked to Asn [1 instances]
a-D-Manp-(1-6)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #1516 [1 instances]
a-D-Manp-(1-3)-b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn
Structure entry #229: N-Glycan fragment GlcNAc1 [3 instances]
b-D-GlcpNAc-(1-4)-Asn