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Title: The Vo region of human V-ATPase in state 1 (focused refinement)

Description: V-type proton ATPase 116 kDa subunit a isoform 1, V-type proton ATPase subunit S1, Renin receptor, V-type proton ATPase 21 kDa proteolipid subunit, V-type proton ATPase 16 kDa proteolipid subunit, V-type proton ATPase subunit d 1, V-type proton ATPase sub

Keywords: V-ATPase, proton pump, MEMBRANE PROTEIN

Source: Homo sapiens

Experimental method: ELECTRON MICROSCOPY

Release date: 2020-11-11

Entity 1: V-type proton ATPase 21 kDa proteolipid subunit

Type: polymer

Polymer type: polypeptide(L)

Synonyms: V-ATPase 21 kDa proteolipid subunit,Vacuolar proton pump 21 kDa proteolipid subunit,hATPL

UniProt: Q99437

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 2: V-type proton ATPase 16 kDa proteolipid subunit

Strand: 1,2,3,4,5,6,7,8,9

Type: polymer

Polymer type: polypeptide(L)

Synonyms: V-ATPase 16 kDa proteolipid subunit,Vacuolar proton pump 16 kDa proteolipid subunit

UniProt: P27449

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 3: V-type proton ATPase subunit d 1

Strand: Q

Type: polymer

Polymer type: polypeptide(L)

Synonyms: V-ATPase subunit d 1,32 kDa accessory protein,V-ATPase 40 kDa accessory protein,V-ATPase AC39 subunit,p39,Vacuolar proton pump subunit d 1

UniProt: P61421

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 4: V-type proton ATPase 116 kDa subunit a isoform 1

Strand: R

Type: polymer

Polymer type: polypeptide(L)

Synonyms: V-ATPase 116 kDa isoform a1,Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit,Vacuolar adenosine triphosphatase subunit Ac116,Vacuolar proton pump subunit 1,Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1

UniProt: Q93050

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 5: V-type proton ATPase subunit e 1

Strand: S

Type: polymer

Polymer type: polypeptide(L)

Synonyms: V-ATPase subunit e 1,V-ATPase 9.2 kDa membrane accessory protein,V-ATPase M9.2 subunit,Vacuolar proton pump subunit e 1

UniProt: O15342

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 6: Ribonuclease kappa

Strand: T

Type: polymer

Polymer type: polypeptide(L)

Synonyms: RNase kappa

EC number: 3.1.-.-

UniProt: Q6P5S7

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 7: V-type proton ATPase subunit S1

Strand: U

Type: polymer

Polymer type: polypeptide(L)

Synonyms: V-ATPase subunit S1,Protein XAP-3,V-ATPase Ac45 subunit,V-ATPase S1 accessory protein,Vacuolar proton pump subunit S1

UniProt: Q15904

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 8: Renin receptor

Strand: V

Type: polymer

Polymer type: polypeptide(L)

Synonyms: ATPase H(+)-transporting lysosomal accessory protein 2,ATPase H(+)-transporting lysosomal-interacting protein 2,ER-localized type I transmembrane adapter,Embryonic liver differentiation factor 10,N14F,Renin/prorenin receptor,Vacuolar ATP synthase membrane

UniProt: O75787

Source: Homo sapiens (Taxonomy ID: 9606)

Entity 10: beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose

Type: branched

Entity 11: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose

Type: branched

Entity 12: alpha-D-glucopyranose-(1-2)-alpha-D-glucopyranose-(1-3)-alpha-D-glucopyranose-(1-3)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-a

Type: branched

Entity 13: tri(methyl)-[2-[[(2~{R})-2-[(~{Z})-octadec-9-enoyl]oxy-3-[(~{E})-1-oxidanylideneoctadec-9-enoxy]propoxy]-oxidanyl-phosphoryl]oxyethyl]azanium

Type: non-polymer

Entity 14: PHOSPHATIDYLETHANOLAMINE

Type: non-polymer

Entity 15: (2~{S})-2-$l^{4}-azanyl-3-[[(2~{R})-3-octadecanoyloxy-2-oxidanyl-propoxy]-oxidanyl-oxidanylidene-$l^{6}-phosphanyl]oxy-propanoic acid

Type: non-polymer

Entity 16: CHOLESTEROL

Type: non-polymer

Entity 17: 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE

Type: non-polymer

Entity 18: methyl (3R,6Z,10E,14E)-3,7,11,15,19-pentamethylicosa-6,10,14,18-tetraen-1-yl dihydrogen diphosphate

Type: non-polymer

Entity 19: 2-acetamido-2-deoxy-beta-D-glucopyranose

Type: non-polymer

Entity 9: beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)-[N-acetyl-alpha-neuraminic acid-(2-3)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose

Type: branched

Structure entry #2677 [1 instances]

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp | a-D-Neup5Ac-(2-3)+

: 15

: 101

Taxons

Structure entry #31585 [1 instances]

b-D-Galp-(1-3)-a-D-GalpNAc-(1-4)+ | D-Galp | a-D-Neup5Ac-(2-3)+

: 2

no Ref

Taxons

Structure entry #548: N-Glycan fragment GlcNAc2 [4 instances]

b-D-GlcpNAc-(1-4)-b-D-GlcpNAc-(1-4)-Asn

: 4263

: 6

Taxons: 1

Structure entry #22572 [1 instances]

b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1-4)-ASN

: 115

no Ref

Taxons

Structure entry #229: N-Glycan fragment GlcNAc1 [1 instances]

b-D-GlcpNAc-(1-4)-Asn

Structure entry #31586 [1 instances]

b-D-Manp-(1-6)-a-D-Manp-(1-6)+ | b-D-Manp-(1-4)-b-D-GlcpNAc-(1-4)-a-D-GlcpNAc-(1-0)-Dolichol-PP | a-D-Glcp-(1-2)-a-D-Glcp-(1-3)-a-D-Glcp-(1-3)-a-D-Manp-(1-2)-a-D-Manp-(1-2)-a-D-Manp-(1-3)+

: 2

no Ref

Taxons

Reference #22397

Wang L; Wu D; Robinson CV; Wu H; Fu TM

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

Published 2020 in Mol Cell

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