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Glycosciences.DB structure entry #8067: 3'-Sialyl T antigen (alpha-anomeric form)
a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)-a-D-GalpNAc
[][A-D-GALPNAC]{[(3+1)][B-D-GALP]{[(3+2)][A-D-NEUP5AC]{}}}
RES
1b:a-dgal-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="4" anomer="a" superclass="non" ringStart="2" ringEnd="6" name="a-dgro-dgal-NON-2:6|1:a|2:keto|3:d">
<stemtype id="1" type="dgro" />
<stemtype id="2" type="dgal" />
<modification type="a" pos_one="1" />
<modification type="keto" pos_one="2" />
<modification type="d" pos_one="3" />
</basetype>
<substituent id="5" name="n-acetyl" />
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="3" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="3" />
<child pos="2" />
</linkage>
</connection>
<connection id="4" parent="4" child="5">
<linkage id="4" parentType="d" childType="n">
<parent pos="5" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>

1 - 5 of 12 entries with matching glycan part

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)-a-D-GalpNAc-(1-1)-Ethyl
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Taxons |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)-a-D-GalpNAc-(1-1)-<Ethylbromide>
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Taxons |

a-D-Neup5Ac-(2-3/6)-b-D-Galp-(1-3)-a-D-GalpNAc
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Taxons: 1 |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)-Ser
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Taxons: 6 |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)-Thr
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Taxons: 2 |
- O-glycan core1 (Show) (Search Database)
- 3'Sialyl T antigen
- Sialyl T antigen
- sTa
Chemical Formula: | C25H42N2O19 | #C | #H | #O | #N | |
Molec. Weight: | 674 | 25 | 42 | 19 | 2 | |
# Atoms: | 88 | |||||
# Residues: | 3 | |||||
# Heavy Atoms: | 46 |
Superclasses:
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Residues:
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1 - 4 of 4 PDB entries

PDB ID 6efd:
Hsa Siglec and Unique domains in complex with the sialyl T antigen trisaccharide
Description:
Source: Streptococcus gordonii str. Challis
Experimental method: X-RAY DIFFRACTION
Resolution: 1.85Å
Release date: 2020-02-19
Entry features 1 distinct glycan structures [1 instances].

PDB ID 5ij3:
SrpA adhesin in complex with sialyl T antigen
Description: Platelet-binding glycoprotein
Source: Streptococcus sanguinis (strain SK36)
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7Å
Release date: 2017-02-08
Entry features 1 distinct glycan structures [1 instances].

PDB ID 5iuc:
Crystal structure of the GspB siglec domain with sialyl T antigen bound
Description: Platelet binding protein GspB
Source: Streptococcus gordonii
Experimental method: X-RAY DIFFRACTION
Resolution: 1.253Å
Release date: 2016-04-13
Entry features 1 distinct glycan structures [2 instances].

Description:
Source:
Experimental method: X-ray Diffraction
Resolution: 1.52Å
Release date:
Entry features 1 distinct glycan structures [4 instances].
1 - 5 of 8 literature references

Reference #21986
Zhang J; Zhang Z; Holst S; Blöchl C; Madunic K; Wuhrer M; Ten Dijke P; Zhang T
Transforming growth factor-β challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells.
Published 2022 in J Biol Chem, 298: 101717
Reference contains 26 structures

Reference #21813
White B; Patterson M; Karnwal S; Brooks CL
Crystal structure of a human MUC16 SEA domain reveals insight into the nature of the CA125 tumor marker.
Published 2022 in Proteins, : epub ahead of print
Reference contains 11 structures

Reference #20891
Pearce OMT
Cancer glycan epitopes: biosynthesis, structure and function.
Published 2018 in Glycobiology, 28: 670-696
Reference contains 26 structures

Reference #20556
Bensing BA; Khedri Z; Deng L; Yu H; Prakobphol A; Fisher SJ; Chen X; Iverson TM; Varki A; Sullam PM
Novel aspects of sialoglycan recognition by the Siglec-like domains of streptococcal SRR glycoproteins.
Published 2016 in Glycobiology, 26: 1222-1234
Reference contains 11 structures

Reference #21045
Joncquel Chevalier Curt M; Lecointe K; Mihalache A; Rossez Y; Gosset P; Léonard R; Robbe-Masselot C
Alteration or adaptation, the two roads for human gastric mucin glycosylation infected by Helicobacter pylori.
Published 2015 in Glycobiology, 25: 617-31
Reference contains 51 structures
1 - 3 of 3 literature references from PDB entries

Reference #22086
Bensing BA; Stubbs HE; Agarwal R; Yamakawa I; Luong K; Solakyildirim K; Yu H; Hadadianpour A; Castro MA; Fialkowski KP; Morrison KM; Wawrzak Z; Chen X; Lebrilla CB; Baudry J; Smith JC; Sullam PM; Iverson TM
Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation.
Published 2022 in Nat Commun, 13: 2753

Reference #20156
Loukachevitch LV; Bensing BA; Yu H; Zeng J; Chen X; Sullam PM; Iverson TM
Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.
Published 2016 in Biochemistry, :

Reference #17908
Pyburn TM; Bensing BA; Xiong YQ; Melancon BJ; Tomasiak TM; Ward NJ; Yankovskaya V; Oliver KM; Cecchini G; Sulikowski GA; Tyska MJ; Sullam PM; Iverson TM
A structural model for binding of the serine-rich repeat adhesin GspB to host carbohydrate receptors.
Published 2011 in PLoS Pathog., 7: e1002112
Consortium for Functional Glycomics (CFG):
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