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Glycosciences.DB structure entry #672: Thomsen-Friedenreich (TF) antigen / Mucin-type O-glycan core 1 (Ser-linked)
b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)-Ser
[][SER]{[(3+1)][A-D-GALPNAC]{[(3+1)][B-D-GALP]{}}}
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
</linkages>
<aglyca>
<historicalData>
<entry id="0" name="SER" toResidue="1">
<linkage parentType="n" childType="x">
<parent pos="3" />
<child pos="1" />
</linkage>
</entry>
</historicalData>
</aglyca>
</sugar>

1 - 5 of 44 entries with matching glycan part

b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)+
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b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)+ Ser
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Ser-(1-2)+
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b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)-Ser-(1-2)+
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b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)+
|
Thr-(1-2)-Ser-(1-2)-Ser
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Ala-(1-2)-Pro-(1-2)+
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Taxons |

b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-3)-a-D-GalpNAc-(1-3)+ Thr
| |
Ser-(1-2)+
|
Ser-(1-2)+
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Taxons |

b-D-Galp-(1-3)-a-D-GalpNAc
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Taxons: 3 |

b-D-Galp-(1-3)-a-D-GalpNAc-(1-1)-<Crotyl-KLH/HSA>
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Taxons |
- O-glycan core1 (Show) (Search Database)
- Thomsen-Friedenreich antigen
- TF antigen
- T antigen
- Thomsen-Friedenreich antigen
- TF antigen
- T antigen
Chemical Formula: | C17H30N2O12 | #C | #H | #O | #N | |
Molec. Weight: | 454 | 17 | 30 | 12 | 2 | |
# Atoms: | 61 | |||||
# Residues: | 3 | |||||
# Heavy Atoms: | 31 |
Superclasses:
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Residues:
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1 - 5 of 7 PDB entries

PDB ID 7jtv:
Structure of IMPa from Pseudomonas aeruginosa in complex with an O-glycopeptide
Description: Immunomodulating metalloprotease (E.C.3.4.24.-), GLU-ALA-PRO-SER-ALA
Source: Pseudomonas aeruginosa
Experimental method: X-RAY DIFFRACTION
Resolution: 2.45Å
Release date: 2020-12-16
Entry features 1 distinct glycan structures [2 instances].

PDB ID 5kdx:
IMPa metallopeptidase in complex with T-antigen
Description: Metallopeptidase
Source:
Experimental method: X-RAY DIFFRACTION
Resolution: 2.4Å
Release date: 2017-01-11
Entry features 1 distinct glycan structures [2 instances].

PDB ID 5a58:
The structure of GH101 D764N mutant from Streptococcus pneumoniae TIGR4 in complex with serinyl T-antigen
Description: ENDO-ALPHA-GALACTOSAMINIDASE
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8Å
Release date: 2015-09-02
Entry features 1 distinct glycan structures [1 instances].

PDB ID 4i4y:
BEL beta-trefoil complex with T-Antigen
Description: BEL beta-trefoil
Source: Boletus edulis
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9Å
Release date: 2013-04-24
Entry features 1 distinct glycan structures [6 instances].

PDB ID 1y2v:
Crystal structure of the common edible mushroom (Agaricus bisporus) lectin in complex with T-antigen
Description: lectin
Source: Agaricus bisporus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9Å
Release date: 2004-12-21
Entry features 1 distinct glycan structures [2 instances].
1 - 5 of 75 literature references

Reference #21993
Konstantinidi A; Nason R; Čaval T; Sun L; Sørensen DM; Furukawa S; Ye Z; Vincentelli R; Narimatsu Y; Vakhrushev SY; Clausen H
Exploring the glycosylation of mucins by use of O-glycodomain reporters recombinantly expressed in glycoengineered HEK293 cells.
Published 2022 in J Biol Chem, 298: 101784
Reference contains 10 structures

Reference #21956
Sim L; Thompson N; Geissner A; Withers SG; Wakarchuk WW
Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.
Published 2022 in Glycobiology, 32: 429-440
Reference contains 12 structures

Reference #21599
Wardman JF; Rahfeld P; Liu F; Morgan-Lang C; Sim L; Hallam SJ; Withers SG
Discovery and Development of Promiscuous O-Glycan Hydrolases for Removal of Intact Sialyl T-Antigen.
Published 2021 in ACS Chem Biol, 16: 2004-2015
Reference contains 8 structures

Reference #21629
Stewart TJ; Takahashi K; Xu N; Prakash A; Brown R; Raska M; Renfrow MB; Novak J
Quantitative assessment of successive carbohydrate additions to the clustered O-glycosylation sites of IgA1 by glycosyltransferases.
Published 2021 in Glycobiology, 31: 540-556
Reference contains 12 structures

Reference #21698
Zeng J; Aryal RP; Stavenhagen K; Luo C; Liu R; Wang X; Chen J; Li H; Matsumoto Y; Wang Y; Wang J; Ju T; Cummings RD
Cosmc deficiency causes spontaneous autoimmunity by breaking B cell tolerance.
Published 2021 in Sci Adv, 7: eabg9118
Reference contains 2 structures
1 - 3 of 3 literature references from PDB entries

Reference #19304
Gregg KJ; Suits MD; Deng L; Vocadlo DJ; Boraston AB
Structural Analysis of a Family 101 Glycoside Hydrolase in Complex with Carbohydrates Reveals Insights into Its Mechanism.
Published 2015 in J. Biol. Chem., 290: 25657-69

Reference #18366
Bovi M; Cenci L; Perduca M; Capaldi S; Carrizo ME; Civiero L; Chiarelli LR; Galliano M; Monaco HL
BEL β-trefoil: a novel lectin with antineoplastic properties in king bolete (Boletus edulis) mushrooms.
Published 2013 in Glycobiology, 23: 578-92

Reference #16423
Carrizo ME; Irazoqui FJ; Lardone RD; Nores GA; Curtino JA; Capaldi S; Perduca M; Monaco HL
Crystallization and preliminary X-ray study of the common edible mushroom (Agaricus bisporus) lectin.
Published 2004 in Acta Crystallogr. D Biol. Crystallogr., 60: 718-20
NCBI Taxonomy ID | Scientific Name |
10029 | Cricetulus griseus |
9606 | Homo sapiens |
10090 | Mus musculus |
9986 | Oryctolagus cuniculus |
Consortium for Functional Glycomics (CFG):
GlycoEpitope DB:
GlycoEpitope DB:
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