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Glycosciences.DB structure entry #6648:

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Format: CarbBank LINUCS GlycoCT_condensed GlycoCT_xml


 b-D-Galp-(1-4)+
               |
          b-D-GlcpNAc-(1-3)-b-D-Galp
               |
 a-L-Fucp-(1-3)+


RES
1b:b-dgal-HEX-1:5
2b:b-dglc-HEX-1:5
3s:n-acetyl
4b:a-lgal-HEX-1:5|6:d
5b:b-dgal-HEX-1:5
LIN
1:1o(3+1)2d
2:2d(2+1)3n
3:2o(3+1)4d
4:2o(4+1)5d


<?xml version="1.0" encoding="UTF-8"?>
 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 <basetype id="2" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
 <stemtype id="1" type="dglc" />
 </basetype>
 <substituent id="3" name="n-acetyl" />
 <basetype id="4" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
 <stemtype id="1" type="lgal" />
 <modification type="d" pos_one="6" />
 </basetype>
 <basetype id="5" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="o" childType="d">
 <parent pos="3" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="2" parent="2" child="3">
 <linkage id="2" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="3" parent="2" child="4">
 <linkage id="3" parentType="o" childType="d">
 <parent pos="3" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="4" parent="2" child="5">
 <linkage id="4" parentType="o" childType="d">
 <parent pos="4" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 </sugar>

SNFG-style Graphics

3D Structure Model

download coordinates

Corresponding entries: 3

1 - 3 of 3 entries with matching glycan part

Structure entry #8768:

b-D-Galp-(1-4)+ | b-D-GlcpNAc-(1-3)-b-D-Galp-(1-1)-Methyl | a-L-Fucp-(1-3)+

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #17656:

b-D-Galp-(1-4)+ | b-D-GlcpNAc-(1-3)-b-D-Galp-(1-1)-<4-Trifluoroacetamidophenol> | a-L-Fucp-(1-3)+

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #28763:

D-Neu5Ac

no 3d model

no NMR spectra

literature references

no GlycoMaps

Lewis X (Show) (Search Database)

General Structure Data

Chemical Formula:	C₂₆H₄₅N₁O₂₀		#C	#H	#O	#N
Molec. Weight:	691		26	45	20	1
# Atoms:	92
# Residues:	4
# Heavy Atoms:	47

Superclasses:

Hex
Hex	2
dHex	1
HexNAc	1

Residues:

Residue	Count
A-L-FUCP	1
B-D-GALP	2
B-D-GLCPNAC	1

PDB references: 5

1 - 5 of 5 PDB entries

PDB ID 5o7u: Crystal structure of the 7-Fluorotryptophan RSL lectin in complex with Lewis x tetrasaccharide

Description: Putative fucose-binding lectin protein

Source: Ralstonia solanacearum

Experimental method: X-RAY DIFFRACTION

Resolution: 1.15Å

Release date: 2018-06-06

Entry features 4 distinct glycan structures [4 instances].

PDB ID 5o7w: Crystal structure of the 4-FLUORO RSL lectin in complex with Lewis x tetrasaccharide

Description: Fucose-binding lectin protein

Source: Ralstonia solanacearum

Experimental method: X-RAY DIFFRACTION

Resolution: 1.35Å

Release date: 2018-06-06

Entry features 3 distinct glycan structures [3 instances].

PDB ID 5a70: Structure of the LecB lectin from Pseudomonas aeruginosa strain PA14 in complex with lewis x tetrasaccharide

Description: LECB

Source: PSEUDOMONAS AERUGINOSA

Experimental method: X-RAY DIFFRACTION

Resolution: 1.6Å

Release date: 2016-07-27

Entry features 1 distinct glycan structures [4 instances].

PDB ID 3zw1: Structure of Bambl lectine in complex with lewix x antigen

Description: BAMBL LECTIN

Source: BURKHOLDERIA AMBIFARIA

Experimental method: X-RAY DIFFRACTION

Resolution: 1.6Å

Release date: 2011-11-16

Entry features 2 distinct glycan structures [4 instances].

PDB ID 1sl5: Crystal Structure of DC-SIGN carbohydrate recognition domain complexed with LNFP III (Dextra L504).

Description: mDC-SIGN1B type I isoform

Source: Homo sapiens

Experimental method: X-RAY DIFFRACTION

Resolution: 1.8Å

Release date: 2004-06-15

Entry features 1 distinct glycan structures [1 instances].

Conformational maps: 3

Map ID: 8362

Disaccharide Fragment: a-L-Fucp-(1-3)-b-D-GlcpNAc

Linkage Path: 33

Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Map ID: 8363

Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc

Linkage Path: 34

Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Map ID: 8364

Disaccharide Fragment: b-D-GlcpNAc-(1-3)-b-D-Galp

Linkage Path: 3

Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Literature references: 5

1 - 5 of 5 literature references

Reference #20857

Sletmoen M; Gerken TA; Stokke BT; Burchell J; Brewer CF

Tn and STn are members of a family of carbohydrate tumor antigens that possess carbohydrate-carbohydrate interactions.

Published 2018 in Glycobiology, 28: 437-442

Reference contains 13 structures

Reference #7889

Ito K; Handa K; Hakomori SI

Species-specific expression of sialosyl-Lex on polymorphonuclear leukocytes (PMN), in relation to selectin-dependent PMN responses

Published 1994 in Glycoconj J, 11: 232-237

Reference contains 5 structures

Reference #8085

Nakayama J; Ota H; Katsuyama T; Kanai M; Taki T; Hirabayashi Y; Suzuki Y

Immunohistochemical demonstration of glycoconjugates bearing the type 2 chain-backbone structure in human fetal, normal and neoplastic gastrointestinal tract

Published 1992 in Histochemistry, 97: 303-310

Reference contains 8 structures

Reference #3165

Nakasaki H; Mitomi T; Noto T; Ogoshi K; Hanaue H; Tanaka Y; Makuuchi H; Clausen H; Hakomori S

Mosaicism in the expression of tumor-associated carbohydrate antigens in human colonic and gastric cancers

Published 1989 in Cancer Res, 49: 3662-3669

Reference contains 4 structures

Reference #11808

Kaieda H; Yamada K; Yamawaki N

Induced immune cells against cancer

Published 1986 in Jpn Kokai Tokkyo Koho, 0: 1-5

Reference contains 1 structure

Further literature references from PDB entries: 2

1 - 2 of 2 literature references from PDB entries

Reference #18634

Topin J; Arnaud J; Sarkar A; Audfray A; Gillon E; Perez S; Jamet H; Varrot A; Imberty A; Thomas A

Deciphering the glycan preference of bacterial lectins by glycan array and molecular docking with validation by microcalorimetry and crystallography.

Published 2013 in PLoS ONE, 8: e71149

Reference #16468

Guo Y; Feinberg H; Conroy E; Mitchell DA; Alvarez R; Blixt O; Taylor ME; Weis WI; Drickamer K

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.

Published 2004 in Nat. Struct. Mol. Biol., 11: 591-8

NCBI Taxonomy ID	Scientific Name
9606	Homo sapiens

Consortium for Functional Glycomics (CFG):

carbPDB_00011_D000

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