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Glycosciences.DB structure entry #603: Tn antigen (Ser-linked)
a-D-GalpNAc-(1-3)-Ser
[][SER]{[(3+1)][A-D-GALPNAC]{}}
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<substituent id="2" name="n-acetyl" />
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
</linkages>
<aglyca>
<historicalData>
<entry id="0" name="SER" toResidue="1">
<linkage parentType="n" childType="x">
<parent pos="3" />
<child pos="1" />
</linkage>
</entry>
</historicalData>
</aglyca>
</sugar>
3D Structure Model1 - 5 of 32 entries with matching glycan part
Structure entry #572: SS dipeptide with two Tn antigens
a-D-GalpNAc-(1-3)+
|
Ser
|
a-D-GalpNAc-(1-3)-Ser-(1-2)+
 |
 |
 |
 : 1 |
 |
Taxons |
Structure entry #573: TT dipeptide with two Tn antigens
a-D-GalpNAc-(1-3)+
|
Thr
|
a-D-GalpNAc-(1-3)-Thr-(1-2)+
|
|
|
: 1 |
|
Taxons |
Structure entry #579: APTSS peptide with Tn antigen at Thr3
a-D-GalpNAc-(1-3)+
|
Thr-(1-2)-Ser-(1-2)-Ser
|
Ala-(1-2)-Pro-(1-2)+
|
|
|
: 1 |
|
Taxons |
Structure entry #580: APTSSTKKT peptide with Tn antigen at Thr3
a-D-GalpNAc-(1-3)+
|
Thr-(1-2)-Ser-(1-2)-Ser-(1-2)-Thr-(1-2)-Lys-(1-2)-Lys-(1-2)-Thr
|
Ala-(1-2)-Pro-(1-2)+
|
|
|
: 1 |
|
Taxons |
Structure entry #581: APTSSST peptide with Tn antigen at Thr3
a-D-GalpNAc-(1-3)+
|
Thr-(1-2)-Ser-(1-2)-Ser-(1-2)-Ser-(1-2)-Thr
|
Ala-(1-2)-Pro-(1-2)+
|
|
|
: 1 |
|
Taxons |
- Tn antigen
| Chemical Formula: | C11H20N2O7 | #C | #H | #O | #N | |
| Molec. Weight: | 292 | 11 | 20 | 7 | 2 | |
| # Atoms: | 40 | |||||
| # Residues: | 2 | |||||
| # Heavy Atoms: | 20 | |||||
Superclasses:
|
Residues:
|
||||||||||
PDB references: 101 - 5 of 10 PDB entries
PDB ID 7vac:
Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoST)
Description:
Source: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 3.5Å
Release date: 2022-08-31
Entry features 4 distinct glycan structures [6 instances].
PDB ID 7vaz:
Crystal structure of antibody 14A in complex with MUC1 glycopeptide(GlycoS)
Description:
Source: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.73Å
Release date: 2022-08-31
Entry features 1 distinct glycan structures [1 instances].
PDB ID 6w12:
Structure of the CRD of CLEC10A
Description: C-type lectin domain family 10 member A
Source: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2Å
Release date: 2021-03-10
Entry features 1 distinct glycan structures [1 instances].
PDB ID 5kd8:
BT_4244 metallopeptidase in complex with Tn antigen.
Description: Metallopeptidase
Source:
Experimental method: X-RAY DIFFRACTION
Resolution: 2.3Å
Release date: 2017-01-11
Entry features 1 distinct glycan structures [1 instances].
PDB ID 5t5j:
LECTIN FROM BAUHINIA FORFICATA IN COMPLEX WITH TN-PEPTIDE
Description: Lectin, TN ANTIGEN ACA-SER-SER-VAL-GLY
Source: Bauhinia forficata
Experimental method: X-RAY DIFFRACTION
Resolution: 1.35Å
Release date: 2016-12-28
Entry features 1 distinct glycan structures [2 instances].
Literature references: 961 - 5 of 96 literature references
Reference #21881
Cecioni S; Ashmus RA; Gilormini PA; Zhu S; Chen X; Shan X; Gros C; Deen MC; Wang Y; Britton R; Vocadlo DJ
Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates.
Published 2022 in Nat Chem Biol, : Online ahead of print
Reference contains 5 structures
Reference #22037
Beaman EM; Carter DRF; Brooks SA
GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?
Published 2022 in Glycobiology, 32: 556-579
Reference contains 4 structures
Reference #21766
Rodriguez E; Boelaars K; Brown K; Madunić K; van Ee T; Dijk F; Verheij J; Li RJE; Schetters STT; Meijer LL; Le Large TYS; Driehuis E; Clevers H; Bruijns SCM; O'Toole T; van Vliet SJ; Bijlsma MF; Wuhrer M; Kazemier G; Giovannetti E; Garcia-Vallejo JJ; va
Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits.
Published 2022 in Commun Biol, 5: 41
Reference contains 10 structures
Reference #21949
Festari MF; da Costa V; Rodríguez-Zraquia SA; Costa M; Landeira M; Lores P; Solari-Saquieres P; Kramer MG; Freire T
The tumor-associated Tn antigen fosters lung metastasis and recruitment of regulatory T cells in triple negative breast cancer.
Published 2022 in Glycobiology, 32: 366-379
Reference contains 2 structures
Reference #22495
Wu AM
Loci and motifs of the GalNAcα1 → 3/O related glycotopes in the mammalian glycoconjugates and their lectin recognition roles.
Published 2022 in Glycoconj J, 39: 633-651
Reference contains 38 structures
1 - 1 of 1 literature references from PDB entries
Reference #19241
Martínez-Sáez N; Castro-López J; Valero-González J; Madariaga D; Compañón I; Somovilla VJ; Salvadó M; Asensio JL; Jiménez-Barbero J; Avenoza A; Busto JH; Bernardes GJ; Peregrina JM; Hurtado-Guerrero R; Corzana F
Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody.
Published 2015 in Angew. Chem. Int. Ed. Engl., 54: 9830-4
| NCBI Taxonomy ID | Scientific Name |
| 96820 | Armadillo |
| 10029 | Cricetulus griseus |
| 9606 | Homo sapiens |
| 12721 | Human immunodeficiency virus |
| 10090 | Mus musculus |
| 9986 | Oryctolagus cuniculus |
| 9940 | Ovis aries |
| 5811 | Toxoplasma gondii |
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