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Glycosciences.DB structure entry #603: Tn antigen (Ser-linked)


 a-D-GalpNAc-(1-3)-Ser


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 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 <substituent id="2" name="n-acetyl" />
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 <aglyca>
 <historicalData>
 <entry id="0" name="SER" toResidue="1">
 <linkage parentType="n" childType="x">
 <parent pos="3" />
 <child pos="1" />
 </linkage>
 </entry>
 </historicalData>
 </aglyca>
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download coordinates

Corresponding entries: 32

1 - 5 of 32 entries with matching glycan part

Structure entry #572: SS dipeptide with two Tn antigens

a-D-GalpNAc-(1-3)+ | Ser | a-D-GalpNAc-(1-3)-Ser-(1-2)+

: 1

Taxons

Structure entry #573: TT dipeptide with two Tn antigens

a-D-GalpNAc-(1-3)+ | Thr | a-D-GalpNAc-(1-3)-Thr-(1-2)+

: 1

Taxons

Structure entry #579: APTSS peptide with Tn antigen at Thr3

a-D-GalpNAc-(1-3)+ | Thr-(1-2)-Ser-(1-2)-Ser | Ala-(1-2)-Pro-(1-2)+

: 1

Taxons

Structure entry #580: APTSSTKKT peptide with Tn antigen at Thr3

a-D-GalpNAc-(1-3)+ | Thr-(1-2)-Ser-(1-2)-Ser-(1-2)-Thr-(1-2)-Lys-(1-2)-Lys-(1-2)-Thr | Ala-(1-2)-Pro-(1-2)+

: 1

Taxons

Structure entry #581: APTSSST peptide with Tn antigen at Thr3

a-D-GalpNAc-(1-3)+ | Thr-(1-2)-Ser-(1-2)-Ser-(1-2)-Ser-(1-2)-Thr | Ala-(1-2)-Pro-(1-2)+

Taxons

Tn antigen

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General Structure Data

Chemical Formula:	C₁₁H₂₀N₂O₇	#C	#H	#O	#N
Molec. Weight:	292	11	20	7	2
# Atoms:	40
# Residues:	2
# Heavy Atoms:	20

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Composition

Superclasses:

Hex
HexNAc	1

Residues:

Residue	Count
A-D-GALPNAC	1
SER	1

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PDB references: 8

1 - 5 of 8 PDB entries

PDB ID 6w12: Structure of the CRD of CLEC10A

Description: C-type lectin domain family 10 member A

Source: Homo sapiens

Experimental method: X-RAY DIFFRACTION

Resolution: 2Å

Release date: 2021-03-10

Entry features 1 distinct glycan structures [1 instances].

PDB ID 5kd8: BT_4244 metallopeptidase in complex with Tn antigen.

Description: Metallopeptidase

Source:

Experimental method: X-RAY DIFFRACTION

Resolution: 2.3Å

Release date: 2017-01-11

Entry features 1 distinct glycan structures [1 instances].

PDB ID 5t5j: LECTIN FROM BAUHINIA FORFICATA IN COMPLEX WITH TN-PEPTIDE

Description: Lectin, TN ANTIGEN ACA-SER-SER-VAL-GLY

Source: Bauhinia forficata

Experimental method: X-RAY DIFFRACTION

Resolution: 1.35Å

Release date: 2016-12-28

Entry features 1 distinct glycan structures [2 instances].

PDB ID 5t5l: LECTIN FROM BAUHINIA FORFICATA IN COMPLEX WITH TN-PEPTIDE

Description: Lectin, TN ANTIGEN ACE-SER-SER-VAL-GLY

Source: Bauhinia forficata

Experimental method: X-RAY DIFFRACTION

Resolution: 1.17Å

Release date: 2016-12-28

Entry features 1 distinct glycan structures [2 instances].

PDB ID 4xtp: Crystal structure of a recombinant Vatairea macrocarpa seed lectin complexed with Tn antigen

Description: Recombinant Vatairea macrocarpa seed lectin complexed with Tn antigen

Source: Vatairea macrocarpa

Experimental method: X-RAY DIFFRACTION

Resolution: 1.97Å

Release date: 2016-01-27

Entry features 1 distinct glycan structures [1 instances].

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Literature references: 94

1 - 5 of 94 literature references

Reference #21949

Festari MF; da Costa V; Rodríguez-Zraquia SA; Costa M; Landeira M; Lores P; Solari-Saquieres P; Kramer MG; Freire T

The tumor-associated Tn antigen fosters lung metastasis and recruitment of regulatory T cells in triple negative breast cancer.

Published 2022 in Glycobiology, 32: 366-379

Reference contains 2 structures

Reference #21956

Sim L; Thompson N; Geissner A; Withers SG; Wakarchuk WW

Mammalian sialyltransferases allow efficient Escherichia coli-based production of mucin-type O-glycoproteins but can also transfer Kdo.

Published 2022 in Glycobiology, 32: 429-440

Reference contains 12 structures

Reference #21881

Cecioni S; Ashmus RA; Gilormini PA; Zhu S; Chen X; Shan X; Gros C; Deen MC; Wang Y; Britton R; Vocadlo DJ

Quantifying lysosomal glycosidase activity within cells using bis-acetal substrates.

Published 2022 in Nat Chem Biol, : Online ahead of print

Reference contains 5 structures

Reference #22037

Beaman EM; Carter DRF; Brooks SA

GALNTs: master regulators of metastasis-associated epithelial-mesenchymal transition (EMT)?

Published 2022 in Glycobiology, 32: 556-579

Reference contains 4 structures

Reference #21766

Rodriguez E; Boelaars K; Brown K; Madunić K; van Ee T; Dijk F; Verheij J; Li RJE; Schetters STT; Meijer LL; Le Large TYS; Driehuis E; Clevers H; Bruijns SCM; O'Toole T; van Vliet SJ; Bijlsma MF; Wuhrer M; Kazemier G; Giovannetti E; Garcia-Vallejo JJ; va

Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits.

Published 2022 in Commun Biol, 5: 41

Reference contains 10 structures

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Further literature references from PDB entries: 1

1 - 1 of 1 literature references from PDB entries

Reference #19241

Martínez-Sáez N; Castro-López J; Valero-González J; Madariaga D; Compañón I; Somovilla VJ; Salvadó M; Asensio JL; Jiménez-Barbero J; Avenoza A; Busto JH; Bernardes GJ; Peregrina JM; Hurtado-Guerrero R; Corzana F

Deciphering the Non-Equivalence of Serine and Threonine O-Glycosylation Points: Implications for Molecular Recognition of the Tn Antigen by an anti-MUC1 Antibody.

Published 2015 in Angew. Chem. Int. Ed. Engl., 54: 9830-4

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Taxonomy: 8

NCBI Taxonomy ID	Scientific Name
96820	Armadillo
10029	Cricetulus griseus
9606	Homo sapiens
12721	Human immunodeficiency virus
10090	Mus musculus
9986	Oryctolagus cuniculus
9940	Ovis aries
5811	Toxoplasma gondii

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Crosslinks: 2

Consortium for Functional Glycomics (CFG):

carbOlink_47243_D000

GlycoEpitope DB:

EP0021

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Glycosciences.DB structure entry #603: Tn antigen (Ser-linked)

1 - 5 of 32 entries with matching glycan part

1 - 5 of 8 PDB entries

1 - 5 of 94 literature references

1 - 1 of 1 literature references from PDB entries

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