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Glycosciences.DB structure entry #50: Lewis X trisaccharide (beta-anomeric form)
b-D-Galp-(1-4)+
|
b-D-GlcpNAc
|
a-L-Fucp-(1-3)+
[][B-D-GLCPNAC]{[(3+1)][A-L-FUCP]{}[(4+1)][B-D-GALP]{}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="4" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="1" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>
3D Structure Model1 - 5 of 13 entries with matching glycan part
Structure entry #369:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
|
a-L-Fucp-(1-3)+
 |
 13C: 1 |
 |
 : 3 |
 |
Taxons |
Structure entry #2036:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-<linker-TMR>
|
a-L-Fucp-(1-3)+
|
 |
|
: 1 |
|
Taxons |
Structure entry #2174: Lewis X antigen, CD15
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-3)-<rest of molecule>
|
a-L-Fucp-(1-3)+
|
|
|
: 3 |
|
Taxons: 3 |
Structure entry #2217:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-4)+
| |
b-D-Galp-(1-4)+ a-L-Fucp-(1-3)+ |
| Asn-(1-2)-Ala-(1-2)-Ser-(1-2)-Ala
b-D-GlcpNAc-(1-4)+ |
| | |
a-L-Fucp-(1-3)+ Asn-(1-2)-Gly-(1-2)+
|
Acetate-(1-2)+
|
|
|
: 1 |
|
Taxons |
Structure entry #4554:
b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-7)-benzyl
|
a-L-Fucp-(1-3)+
 |
|
|
: 1 |
|
Taxons |
- Lewis X (Show) (Search Database)
- LewisX
- LeX
- CD15
- Lewis-X
- Le-X
- Lewis X
| Chemical Formula: | C20H35N1O15 | #C | #H | #O | #N | |
| Molec. Weight: | 529 | 20 | 35 | 15 | 1 | |
| # Atoms: | 71 | |||||
| # Residues: | 3 | |||||
| # Heavy Atoms: | 36 | |||||
Superclasses:
|
Residues:
|
||||||||||||||||
PDB references: 51 - 5 of 5 PDB entries
PDB ID 5o7u:
Crystal structure of the 7-Fluorotryptophan RSL lectin in complex with Lewis x tetrasaccharide
Description: Putative fucose-binding lectin protein
Source: Ralstonia solanacearum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.15Å
Release date: 2018-06-06
Entry features 4 distinct glycan structures [4 instances].
PDB ID 5o7v:
Crystal structure of the 5F-tryptophan RSL lectin in complex with Lewis x tetrasaccharide
Description: Putative fucose-binding lectin protein
Source: Ralstonia solanacearum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.28Å
Release date: 2018-06-06
Entry features 3 distinct glycan structures [4 instances].
PDB ID 5ajb:
X-ray structure of the RSL lectin in complex with Lewis X tetrasaccahride
Description: LECTIN
Source: RALSTONIA SOLANACEARUM
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8Å
Release date: 2016-03-02
Entry features 3 distinct glycan structures [5 instances].
PDB ID 4p2n:
Structure of the P domain from a GI.7 Norovirus variant in complex with LeX HBGA
Description: Major capsid protein
Source: Norovirus Hu/GI.7/TCH-060/USA/2003
Experimental method: X-RAY DIFFRACTION
Resolution: 1.7Å
Release date: 2014-04-02
Entry features 1 distinct glycan structures [4 instances].
PDB ID 2ox9:
Mouse Scavenger Receptor C-type Lectin carbohydrate-recognition domain.
Description: Collectin placenta 1
Source: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.95Å
Release date: 2007-04-03
Entry features 1 distinct glycan structures [4 instances].
Conformational maps: 2
Map ID: 8431
Disaccharide Fragment: a-L-Fucp-(1-3)-b-D-GlcpNAc
Linkage Path: 3
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Map ID: 8432
Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc
Linkage Path: 4
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Literature references: 1171 - 5 of 117 literature references
Reference #20916
Taylor ME; Snelling T; Smith DF; Drickamer K
Absence of a human ortholog of rodent Kupffer cell galactose-binding receptor encoded by the CLEC4f gene.
Published 2019 in Glycobiology, 29: 332-345
Reference contains 25 structures
Reference #20735
Meng C; Sasmal A; Zhang Y; Gao T; Liu CC; Khan N; Varki A; Wang F; Cao H
Chemoenzymatic Assembly of Mammalian O-Mannose Glycans.
Published 2018 in Angew. Chem. Int. Ed. Engl., 57: 9003-9007
Reference contains 60 structures
Reference #20805
Schneider M; Al-Shareffi E; Haltiwanger RS
Biological functions of fucose in mammals.
Published 2017 in Glycobiology, 27: 601-618
Reference contains 19 structures
Reference #15480
Topin J; Lelimousin M; Arnaud J; Audfray A; Pérez S; Varrot A; Imberty A
The Hidden Conformation of Lewis x, a Human Histo-Blood Group Antigen, Is a Determinant for Recognition by Pathogen Lectins.
Published 2016 in ACS Chem. Biol., 11: 2011-20
Reference contains 2 structures
Reference #18180
Schubert M; Bleuler-Martinez S; Butschi A; Wälti MA; Egloff P; Stutz K; Yan S; Collot M; Mallet JM; Wilson IB; Hengartner MO; Aebi M; Allain FH; Künzler M
Plasticity of the β-trefoil protein fold in the recognition and control of invertebrate predators and parasites by a fungal defence system.
Published 2012 in PLoS Pathog., 8: e1002706
Reference contains 24 structures
| NCBI Taxonomy ID | Scientific Name |
| 10141 | Cavia porcellus |
| 9534 | Cercopithecus aethiops |
| 10029 | Cricetulus griseus |
| 9031 | Gallus gallus |
| 9606 | Homo sapiens |
| 10090 | Mus musculus |
| 8638 | Naja |
| 9986 | Oryctolagus cuniculus |
| 10114 | Rattus |
| 6183 | Schistosoma mansoni |
Consortium for Functional Glycomics (CFG):
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