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Glycosciences.DB structure entry #50: Lewis X trisaccharide (beta-anomeric form)
b-D-Galp-(1-4)+
|
b-D-GlcpNAc
|
a-L-Fucp-(1-3)+
[][B-D-GLCPNAC]{[(3+1)][A-L-FUCP]{}[(4+1)][B-D-GALP]{}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="4" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="1" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>

1 - 5 of 14 entries with matching glycan part

b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
|
a-L-Fucp-(1-3)+
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Taxons |

b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-<linker-TMR>
|
a-L-Fucp-(1-3)+
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Taxons |

b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-3)-<rest of molecule>
|
a-L-Fucp-(1-3)+
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Taxons: 3 |

b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-4)+
| |
b-D-Galp-(1-4)+ a-L-Fucp-(1-3)+ |
| Asn-(1-2)-Ala-(1-2)-Ser-(1-2)-Ala
b-D-GlcpNAc-(1-4)+ |
| | |
a-L-Fucp-(1-3)+ Asn-(1-2)-Gly-(1-2)+
|
Acetate-(1-2)+
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Taxons |

b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-7)-benzyl
|
a-L-Fucp-(1-3)+
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Taxons |
- Lewis X (Show) (Search Database)
- LewisX
- LeX
- CD15
- Lewis-X
- Le-X
- Lewis X
Chemical Formula: | C20H35N1O15 | #C | #H | #O | #N | |
Molec. Weight: | 529 | 20 | 35 | 15 | 1 | |
# Atoms: | 71 | |||||
# Residues: | 3 | |||||
# Heavy Atoms: | 36 |
Superclasses:
|
Residues:
|
1 - 5 of 7 PDB entries

PDB ID 6hjd:
Cholera toxin classical B-pentamer in complex with Lewis-x
Description: Cholera toxin B subunit
Source: Vibrio cholerae
Experimental method: X-RAY DIFFRACTION
Resolution: 1.54Å
Release date: 2019-08-14
Entry features 3 distinct glycan structures [9 instances].

PDB ID 6r35:
Structure of the LecB lectin from Pseudomonas aeruginosa strain PAO1 in complex with lewis x tetrasaccharide
Description: Fucose-binding lectin PA-IIL
Source: Pseudomonas aeruginosa PAO1
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8Å
Release date: 2019-06-12
Entry features 1 distinct glycan structures [4 instances].

PDB ID 5o7u:
Crystal structure of the 7-Fluorotryptophan RSL lectin in complex with Lewis x tetrasaccharide
Description: Putative fucose-binding lectin protein
Source: Ralstonia solanacearum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.15Å
Release date: 2018-06-06
Entry features 4 distinct glycan structures [4 instances].

PDB ID 5o7v:
Crystal structure of the 5F-tryptophan RSL lectin in complex with Lewis x tetrasaccharide
Description: Putative fucose-binding lectin protein
Source: Ralstonia solanacearum
Experimental method: X-RAY DIFFRACTION
Resolution: 1.28Å
Release date: 2018-06-06
Entry features 3 distinct glycan structures [4 instances].

PDB ID 5ajb:
X-ray structure of the RSL lectin in complex with Lewis X tetrasaccahride
Description: LECTIN
Source: RALSTONIA SOLANACEARUM
Experimental method: X-RAY DIFFRACTION
Resolution: 1.8Å
Release date: 2016-03-02
Entry features 3 distinct glycan structures [5 instances].

Map ID: 8431
Disaccharide Fragment: a-L-Fucp-(1-3)-b-D-GlcpNAc
Linkage Path: 3
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Map ID: 8432
Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc
Linkage Path: 4
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
1 - 5 of 126 literature references

Reference #21006
Gonciarz W; Walencka M; Moran AP; Hinc K; Obuchowski M; Chmiela M
Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection.
Published 2019 in J. Biomed. Sci., 26: 23
Reference contains 2 structures

Reference #20916
Taylor ME; Snelling T; Smith DF; Drickamer K
Absence of a human ortholog of rodent Kupffer cell galactose-binding receptor encoded by the CLEC4f gene.
Published 2019 in Glycobiology, 29: 332-345
Reference contains 25 structures

Reference #21010
Albertó M; Cuello HA; Gulino CA; Pifano M; Belgorosky D; Gabri MR; Eiján AM; Segatori VI
Expression of bladder cancer-associated glycans in murine tumor cell lines.
Published 2019 in Oncol Lett, 17: 3141-3150
Reference contains 5 structures

Reference #21286
van Leeuwen SS
Challenges and Pitfalls in Human Milk Oligosaccharide Analysis.
Published 2019 in Nutrients, 11:
Reference contains 50 structures

Reference #21053
Gutiérrez-Huante K; Salinas-Marín R; Mora-Montes HM; Gonzalez RA; Martínez-Duncker I
Human adenovirus type 5 increases host cell fucosylation and modifies Ley antigen expression.
Published 2019 in Glycobiology, 29: 469-478
Reference contains 3 structures
1 - 2 of 2 literature references from PDB entries

Reference #21145
Lepsik M; Sommer R; Kuhaudomlarp S; Lelimousin M; Paci E; Varrot A; Titz A; Imberty A
Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study.
Published 2019 in Eur J Med Chem, 177: 212-220

Reference #18827
Shanker S; Czako R; Sankaran B; Atmar RL; Estes MK; Prasad BV
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Published 2014 in J. Virol., 88: 6168-80
NCBI Taxonomy ID | Scientific Name |
10141 | Cavia porcellus |
9534 | Cercopithecus aethiops |
10029 | Cricetulus griseus |
9031 | Gallus gallus |
9606 | Homo sapiens |
10090 | Mus musculus |
8638 | Naja |
9986 | Oryctolagus cuniculus |
10114 | Rattus |
6183 | Schistosoma mansoni |
Consortium for Functional Glycomics (CFG):
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