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Glycosciences.DB structure entry #2311: Blood group A trisaccharide (beta-anomeric form)
a-D-GalpNAc-(1-3)+
|
b-D-Galp
|
a-L-Fucp-(1-2)+
[][B-D-GALP]{[(2+1)][A-L-FUCP]{}[(3+1)][A-D-GALPNAC]{}}
RES
1b:b-dgal-HEX-1:5
2b:a-lgal-HEX-1:5|6:d
3b:a-dgal-HEX-1:5
4s:n-acetyl
LIN
1:1o(2+1)2d
2:1o(3+1)3d
3:3d(2+1)4n
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="2" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<substituent id="4" name="n-acetyl" />
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="o" childType="d">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="3" child="4">
<linkage id="3" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>
3D Structure Model1 - 5 of 7 entries with matching glycan part
Structure entry #372:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
|
a-L-Fucp-(1-2)+
 |
 13C: 1 |
 |
 : 5 |
 |
Taxons: 1 |
Structure entry #5986:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-1)-Methyl
|
a-L-Fucp-(1-2)+
|
 |
|
: 6 |
|
Taxons |
Structure entry #6235:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-1)-Ethanolamine-(2-9)-Nonan-1,9-dioate-(1-1)-Methyl
|
a-L-Fucp-(1-2)+
|
|
|
: 2 |
|
Taxons |
Structure entry #7253: Blood group A trisaccharide (beta-anomeric form) linked to Asn
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-4)-Asn
|
a-L-Fucp-(1-2)+
 |
|
|
: 1 |
|
Taxons: 1 |
Structure entry #22211:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-9)-9-hydroxy-Nonanoate-(1-1)-Ethyl
|
a-L-Fucp-(1-2)+
|
|
|
: 2 |
|
Taxons |
- Blood Group A Antigen (Show) (Search Database)
| Chemical Formula: | C20H35N1O15 | #C | #H | #O | #N | |
| Molec. Weight: | 529 | 20 | 35 | 15 | 1 | |
| # Atoms: | 71 | |||||
| # Residues: | 3 | |||||
| # Heavy Atoms: | 36 | |||||
Superclasses:
|
Residues:
|
||||||||||||||||
PDB references: 91 - 5 of 9 PDB entries
PDB ID 4d6e:
Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the blood group A-trisaccharide (X01 mutant)
Description: GLYCOSIDE HYDROLASE (E.C.3.2.1.102)
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 1.45Å
Release date: 2014-11-26
Entry features 1 distinct glycan structures [1 instances].
PDB ID 4ah4:
Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) in complex with BGA Oligosaccharide.
Description: FUCOSE-SPECIFIC LECTIN FLEA
Source: ASPERGILLUS FUMIGATUS
Experimental method: X-RAY DIFFRACTION
Resolution: 1.75Å
Release date: 2013-02-20
Entry features 3 distinct glycan structures [12 instances].
PDB ID 3sld:
Structural characterization of a GII.4 2004 norovirus variant (TCH05) bound to A trisaccharide
Description: Capsid
Source: Norovirus Hu/GII.4/2004/NL
Experimental method: X-RAY DIFFRACTION
Resolution: 2.679Å
Release date: 2011-07-13
Entry features 1 distinct glycan structures [8 instances].
PDB ID 3pa1:
Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with HBGA type A
Description: Capsid protein
Source: Norwalk virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.48Å
Release date: 2011-05-11
Entry features 1 distinct glycan structures [1 instances].
PDB ID 2wmi:
Crystal structure of the catalytic module of a family 98 glycoside hydrolase from Streptococcus pneumoniae SP3-BS71 in complex with the A-trisaccharide blood group antigen.
Description: FUCOLECTIN-RELATED PROTEIN
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9Å
Release date: 2009-07-14
Entry features 1 distinct glycan structures [2 instances].
Conformational maps: 2
Map ID: 8427
Disaccharide Fragment: a-L-Fucp-(1-2)-b-D-Galp
Linkage Path: 2
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Map ID: 8428
Disaccharide Fragment: a-D-GalpNAc-(1-3)-b-D-Galp
Linkage Path: 3
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Literature references: 201 - 5 of 20 literature references
Reference #21971
Yamamoto F
A historical overview of advances in molecular genetic/genomic studies of the ABO blood group system.
Published 2022 in Glycoconj J, 39: 207-218
Reference contains 3 structures
Reference #21626
Rubén LC; Laura MR; Almudena FB; Emilio GM
Glycan array analysis of Pholiota squarrosa lectin and other fucose-oriented lectins.
Published 2021 in Glycobiology, 31: 459-476
Reference contains 10 structures
Reference #21704
Mateoiu C; Vitiazeva V; Kristjansdottir B; Weijdegård B; Örnros J; Gallini R; Kamali-Moghaddam M; Sundfeldt K; Karlsson NG
Analysis of blood group antigens on MUC5AC in mucinous ovarian cancer tissues using in situ proximity ligation assay.
Published 2021 in Glycobiology, 31: 1464-1471
Reference contains 3 structures
Reference #22000
Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.
Published 2021 in Nat Chem Biol, 17: 806-816
Reference contains 65 structures
Reference #21847
Lardone RD; Garay YC; Parodi P; de la Fuente S; Angeloni G; Bravo EO; Schmider AK; Irazoqui FJ
How glycobiology can help us treat and beat the COVID-19 pandemic.
Published 2021 in J Biol Chem, 296: 100375
Reference contains 11 structures
1 - 5 of 9 literature references from PDB entries
Reference #19144
Houser J; Komarek J; Cioci G; Varrot A; Imberty A; Wimmerova M
Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent.
Published 2015 in Acta Crystallogr. D Biol. Crystallogr., 71: 442-53
Reference #19172
Kwan DH; Constantinescu I; Chapanian R; Higgins MA; Kötzler MP; Samain E; Boraston AB; Kizhakkedathu JN; Withers SG
Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.
Published 2015 in J. Am. Chem. Soc., 137: 5695-705
Reference #17898
Shanker S; Choi JM; Sankaran B; Atmar RL; Estes MK; Prasad BV
Structural analysis of histo-blood group antigen binding specificity in a norovirus GII.4 epidemic variant: implications for epochal evolution.
Published 2011 in J. Virol., 85: 8635-45
Reference #17837
Hansman GS; Biertümpfel C; Georgiev I; McLellan JS; Chen L; Zhou T; Katayama K; Kwong PD
Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.
Published 2011 in J. Virol., 85: 6687-701
Reference #17271
Higgins MA; Abbott DW; Boulanger MJ; Boraston AB
Blood group antigen recognition by a solute-binding protein from a serotype 3 strain of Streptococcus pneumoniae.
Published 2009 in J. Mol. Biol., 388: 299-309
| NCBI Taxonomy ID | Scientific Name |
| 9606 | Homo sapiens |
Consortium for Functional Glycomics (CFG):
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