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Glycosciences.DB structure entry #22449: Blood group A type II tetrasaccharide (beta-anomeric form)
[][B-D-GLCPNAC]{[(4+1)][B-D-GALP]{[(2+1)][A-L-FUCP]{}[(3+1)][A-D-GALPNAC]{}}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-lgal-HEX-1:5|6:d
5b:a-dgal-HEX-1:5
6s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3o(2+1)4d
4:3o(3+1)5d
5:5d(2+1)6n
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="4" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="5" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<substituent id="6" name="n-acetyl" />
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="3" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="4" parent="3" child="5">
<linkage id="4" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="5" parent="5" child="6">
<linkage id="5" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>
3D Structure Model1 - 5 of 7 entries with matching glycan part
Structure entry #3807:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Hex-3-en-1,2,5,6-tetrol
|
a-L-Fucp-(1-2)+
 |
 |
 |
 : 2 |
 |
Taxons |
Structure entry #3829:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-4)-b-D-GlcpNAc-(1-6)-Hex-3-en-1,2,5,6-tetrol
|
a-L-Fucp-(1-2)+
|
|
|
: 1 |
|
Taxons: 1 |
Structure entry #5997:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Methyl
|
a-L-Fucp-(1-2)+
|
|
|
: 3 |
|
Taxons |
Structure entry #9030:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-4)-b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
|
a-L-Fucp-(1-2)+
|
|
|
: 1 |
|
Taxons |
Structure entry #19145:
a-D-GalpNAc-(1-3)+
|
b-D-Galp-(1-3/4)-b-D-GlcpNAc
|
a-L-Fucp-(1-2)+
 |
|
|
: 2 |
|
Taxons: 1 |
- Blood Group A Antigen (Show) (Search Database)
- Lactosamine (Show) (Search Database)
| Chemical Formula: | ||
| Molec. Weight: | ||
| # Atoms: | ||
| # Residues: | 4 | |
| # Heavy Atoms: | ||
Superclasses:
|
Residues:
|
||||||||||||||||||
PDB references: 71 - 5 of 7 PDB entries
PDB ID 4d71:
Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A X02 mutant)
Description: GLYCOSIDE HYDROLASE (E.C.3.2.1.102)
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 1.77Å
Release date: 2015-01-21
Entry features 1 distinct glycan structures [1 instances].
PDB ID 4d72:
Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A L19 mutant)
Description: GLYCOSIDE HYDROLASE (E.C.3.2.1.102)
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 2.11Å
Release date: 2015-01-21
Entry features 1 distinct glycan structures [1 instances].
PDB ID 4d6j:
Crystal structure of a family 98 glycoside hydrolase catalytic module (Sp3GH98) in complex with the type 2 blood group A-tetrasaccharide (E558A X01 mutant)
Description: GLYCOSIDE HYDROLASE (E.C.3.2.1.102)
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 1.98Å
Release date: 2014-11-26
Entry features 1 distinct glycan structures [1 instances].
PDB ID 4p26:
Structure of the P domain from a GI.7 Norovirus variant in complex with A-type 2 HBGA
Description: Major capsid protein
Source: Norovirus Hu/GI.7/TCH-060/USA/2003
Experimental method: X-RAY DIFFRACTION
Resolution: 1.9Å
Release date: 2014-04-02
Entry features 1 distinct glycan structures [3 instances].
PDB ID 3wg3:
Crystal structure of Agrocybe cylindracea galectin with blood type A antigen tetraose
Description: Galactoside-binding lectin
Source: Agrocybe cylindracea
Experimental method: X-RAY DIFFRACTION
Resolution: 1.35Å
Release date: 2013-11-27
Entry features 1 distinct glycan structures [2 instances].
Conformational maps: 3
Map ID: 8398
Disaccharide Fragment: a-L-Fucp-(1-2)-b-D-Galp
Linkage Path: 42
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Map ID: 8399
Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc
Linkage Path: 4
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Map ID: 8400
Disaccharide Fragment: a-D-GalpNAc-(1-3)-b-D-Galp
Linkage Path: 43
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
Literature references: 2831 - 5 of 283 literature references
Reference #21992
Blenda AV; Kamili NA; Wu SC; Abel WF; Ayona D; Gerner-Smidt C; Ho AD; Benian GM; Cummings RD; Arthur CM; Stowell SR
Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group-like antigens.
Published 2022 in J Biol Chem, 298: 101704
Reference contains 42 structures
Reference #22000
Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.
Published 2021 in Nat Chem Biol, 17: 806-816
Reference contains 65 structures
Reference #21998
Wang S; Chen C; Gadi MR; Saikam V; Liu D; Zhu H; Bollag R; Liu K; Chen X; Wang F; Wang PG; Ling P; Guan W; Li L
Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics.
Published 2021 in Nat Commun, 12: 3573
Reference contains 51 structures
Reference #21311
Rahfeld P; Withers SG
Towards universal donor blood: enzymatic conversion of A and B to O type.
Published 2019 in J. Biol. Chem., :
Reference contains 17 structures
Reference #21173
Buettner MJ; Shah SR; Saeui CT; Ariss R; Yarema KJ
Improving Immunotherapy Through Glycodesign.
Published 2018 in Front Immunol, 9: 2485
Reference contains 42 structures
1 - 4 of 4 literature references from PDB entries
Reference #19172
Kwan DH; Constantinescu I; Chapanian R; Higgins MA; Kötzler MP; Samain E; Boraston AB; Kizhakkedathu JN; Withers SG
Toward Efficient Enzymes for the Generation of Universal Blood through Structure-Guided Directed Evolution.
Published 2015 in J. Am. Chem. Soc., 137: 5695-705
Reference #18827
Shanker S; Czako R; Sankaran B; Atmar RL; Estes MK; Prasad BV
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Published 2014 in J. Virol., 88: 6168-80
Reference #18650
Kuwabara N; Hu D; Tateno H; Makyio H; Hirabayashi J; Kato R
Conformational change of a unique sequence in a fungal galectin from Agrocybe cylindracea controls glycan ligand-binding specificity.
Published 2013 in FEBS Lett., 587: 3620-5
Reference #18149
Hu L; Crawford SE; Czako R; Cortes-Penfield NW; Smith DF; Le Pendu J; Estes MK; Prasad BV
Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Published 2012 in Nature, 485: 256-9
Consortium for Functional Glycomics (CFG):
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