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Glycosciences.DB structure entry #18363: LewisX trisaccharide (alpha-anomeric form)

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Format: CarbBank LINUCS GlycoCT_condensed GlycoCT_xml


 b-D-Galp-(1-4)+
               |
          a-D-GlcpNAc
               |
 a-L-Fucp-(1-3)+


RES
1b:a-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d


<?xml version="1.0" encoding="UTF-8"?>
 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-dglc-HEX-1:5">
 <stemtype id="1" type="dglc" />
 </basetype>
 <substituent id="2" name="n-acetyl" />
 <basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
 <stemtype id="1" type="lgal" />
 <modification type="d" pos_one="6" />
 </basetype>
 <basetype id="4" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="2" parent="1" child="3">
 <linkage id="2" parentType="o" childType="d">
 <parent pos="3" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="3" parent="1" child="4">
 <linkage id="3" parentType="o" childType="d">
 <parent pos="4" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 </sugar>

SNFG-style Graphics

3D Structure Model

download coordinates

Corresponding entries: 1

1 - 1 of 1 entries with matching glycan part

Structure entry #7764:

b-D-Galp-(1-4)+ | a-D-GlcpNAc-(1-O)-P | a-L-Fucp-(1-3)+

no NMR spectra

literature references

no GlycoMaps

General Structure Data

Chemical Formula:	C₂₀H₃₅N₁O₁₅		#C	#H	#O	#N
Molec. Weight:	529		20	35	15	1
# Atoms:	71
# Residues:	3
# Heavy Atoms:	36

Superclasses:

Hex
Hex	1
dHex	1
HexNAc	1

Residues:

Residue	Count
A-D-GLCPNAC	1
A-L-FUCP	1
B-D-GALP	1

PDB references: 6

1 - 5 of 6 PDB entries

PDB ID 7vs9: Crystal structure of P domain from norovirus GI.9 capsid protein in complex with Lewis x antigen.

Description:

Source: Norovirus Hu/GI/Vancouver730/2004/CAN

Experimental method: X-RAY DIFFRACTION

Resolution: 2.26Å

Release date: 2022-08-31

Entry features 1 distinct glycan structures [2 instances].

PDB ID 6hjd: Cholera toxin classical B-pentamer in complex with Lewis-x

Description: Cholera toxin B subunit

Source: Vibrio cholerae

Experimental method: X-RAY DIFFRACTION

Resolution: 1.54Å

Release date: 2019-08-14

Entry features 3 distinct glycan structures [9 instances].

PDB ID 6orf: Crystal structure of SpGH29

Description: Glycoside hydrolase

Source: Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)

Experimental method: X-RAY DIFFRACTION

Resolution: 1.7Å

Release date: 2019-07-10

Entry features 1 distinct glycan structures [2 instances].

PDB ID 5ajc: X-ray structure of RSL lectin in complex with sialyl lewis X tetrasaccharide

Description: PUTATIVE FUCOSE-BINDING LECTIN PROTEIN

Source: RALSTONIA SOLANACEARUM

Experimental method: X-RAY DIFFRACTION

Resolution: 1.7Å

Release date: 2016-03-02

Entry features 5 distinct glycan structures [6 instances].

PDB ID 4x0c: Crystal structure of P domain from norovirus strain NSW0514 in complex with HBGA type Lex (triglycan)

Description: Protruding domain of norovirus strain Saga4

Source: Norovirus Hu/GII.4/Sydney/NSW0514/2012/AU

Experimental method: X-RAY DIFFRACTION

Resolution: 1.72Å

Release date: 2014-12-17

Entry features 1 distinct glycan structures [2 instances].

Literature references: 1

1 - 1 of 1 literature references

Reference #10918

Pennington JE; Rastan S; Roelcke D; Feizi T

Saccharide structures of the mouse embryo during the first eight days of development. Inferences from immunocytochemical studies using monoclonal antibodies in conjunction with glycosidases

Published 1985 in J Embryol Exp Morphol, 90: 335-361

Reference contains 2 structures

Further literature references from PDB entries: 4

1 - 4 of 4 literature references from PDB entries

Reference #22468

Kimura-Someya T; Kato-Murayama M; Katsura K; Sakai N; Murayama K; Hanada K; Shirouzu M; Someya Y

Lewis fucose is a key moiety for the recognition of histo-blood group antigens by GI.9 norovirus, as revealed by structural analysis.

Published 2022 in FEBS Open Bio, 12: 560-570

Reference #15480

Topin J; Lelimousin M; Arnaud J; Audfray A; Pérez S; Varrot A; Imberty A

The Hidden Conformation of Lewis x, a Human Histo-Blood Group Antigen, Is a Determinant for Recognition by Pathogen Lectins.

Published 2016 in ACS Chem. Biol., 11: 2011-20

Reference contains 2 structures

Reference #19039

Singh BK; Leuthold MM; Hansman GS

Human noroviruses' fondness for histo-blood group antigens.

Published 2015 in J. Virol., 89: 2024-40

Reference #16468

Guo Y; Feinberg H; Conroy E; Mitchell DA; Alvarez R; Blixt O; Taylor ME; Weis WI; Drickamer K

Structural basis for distinct ligand-binding and targeting properties of the receptors DC-SIGN and DC-SIGNR.

Published 2004 in Nat. Struct. Mol. Biol., 11: 591-8

NCBI Taxonomy ID	Scientific Name
10090	Mus musculus

Consortium for Functional Glycomics (CFG):

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