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Glycosciences.DB structure entry #150: 3'-Sialyl-LewisA tetrasaccharide (beta-anomeric form)
a-L-Fucp-(1-4)+
|
b-D-GlcpNAc
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a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)+
[][B-D-GLCPNAC]{[(3+1)][B-D-GALP]{[(3+2)][A-D-NEUP5AC]{}}[(4+1)][A-L-FUCP]{}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
5s:n-acetyl
6b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:3o(3+2)4d
4:4d(5+1)5n
5:1o(4+1)6d
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="4" anomer="a" superclass="non" ringStart="2" ringEnd="6" name="a-dgro-dgal-NON-2:6|1:a|2:keto|3:d">
<stemtype id="1" type="dgro" />
<stemtype id="2" type="dgal" />
<modification type="a" pos_one="1" />
<modification type="keto" pos_one="2" />
<modification type="d" pos_one="3" />
</basetype>
<substituent id="5" name="n-acetyl" />
<basetype id="6" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="3" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="3" />
<child pos="2" />
</linkage>
</connection>
<connection id="4" parent="4" child="5">
<linkage id="4" parentType="d" childType="n">
<parent pos="5" />
<child pos="1" />
</linkage>
</connection>
<connection id="5" parent="1" child="6">
<linkage id="5" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>

1 - 5 of 7 entries with matching glycan part

a-L-Fucp-(1-4)+
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b-D-GlcpNAc-(1-1)-allyl
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a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)+
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Taxons |

a-L-Fucp-(1-4)+
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b-D-GlcpNAc-(1-3)-<rest of molecule>
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a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)+
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Taxons: 1 |

a-L-Fucp-(1-4)+
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b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
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a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)+
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Taxons |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4/3)+
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b-D-GlcpNAc
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a-L-Fucp-(1-3/4)+
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Taxons |

a-L-Fucp-(1-4)+
|
b-D-GlcpNAc-(1-1)-propanolamine
|
a-D-Neup5Ac-(2-3)-b-D-Galp-(1-3)+
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Taxons |
- Sialyl Lewis A (Show) (Search Database)
- Sialyl-Lewis A
- CA 19-9
- carbohydrate antigen 19-9
- cancer antigen 19-9
Chemical Formula: | C31H52N2O23 | #C | #H | #O | #N | |
Molec. Weight: | 820 | 31 | 52 | 23 | 2 | |
# Atoms: | 108 | |||||
# Residues: | 4 | |||||
# Heavy Atoms: | 56 |
Superclasses:
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Residues:
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1 - 3 of 3 PDB entries

PDB ID 6xuk:
AbLIFT design 15 of Ab 1116NS19.9
Description: Heavy chain, Light chain
Source: Mus musculus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.42Å
Release date: 2021-02-03
Entry features 1 distinct glycan structures [1 instances].

PDB ID 6xun:
Ab 5b1 bound to CA19-9
Description: Heavy chain, Light chain
Source: Homo sapiens
Experimental method: X-RAY DIFFRACTION
Resolution: 2.41Å
Release date: 2021-02-03
Entry features 1 distinct glycan structures [3 instances].

PDB ID 6xtg:
Ab 1116NS19.9 bound to CA19-9
Description: Light chain, Heavy chain
Source: MUS MUSCULUS
Experimental method: X-RAY DIFFRACTION
Resolution: 1.55Å
Release date: 2021-01-27
Entry features 1 distinct glycan structures [1 instances].
1 - 5 of 55 literature references

Reference #22043
Bleuler-Martinez S; Varrot A; Olieric V; Schubert M; Vogt E; Fetz C; Wohlschlager T; Plaza DF; Wälti M; Duport Y; Capitani G; Aebi M; Künzler M
Structure-function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity.
Published 2022 in Glycobiology, 32: 600-615
Reference contains 27 structures

Reference #21703
Ezeabikwa B; Mondal N; Antonopoulos A; Haslam SM; Matsumoto Y; Martin-Caraballo M; Lehoux S; Mandalasi M; Ishaque A; Heimburg-Molinaro J; Cummings RD; Nyame AK
Major differences in glycosylation and fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines.
Published 2021 in Glycobiology, 31: 1444-1463
Reference contains 15 structures

Reference #21814
Roderer D; Bröcker F; Sitsel O; Kaplonek P; Leidreiter F; Seeberger PH; Raunser S
Glycan-dependent cell adhesion mechanism of Tc toxins.
Published 2020 in Nat Commun, 11: 2694
Reference contains 13 structures

Reference #21750
Kudelka MR; Stowell SR; Cummings RD; Neish AS
Intestinal epithelial glycosylation in homeostasis and gut microbiota interactions in IBD.
Published 2020 in Nat Rev Gastroenterol Hepatol, 17: 597-617
Reference contains 35 structures

Reference #21005
Munkley J
The glycosylation landscape of pancreatic cancer.
Published 2019 in Oncol Lett, 17: 2569-2575
Reference contains 9 structures
Consortium for Functional Glycomics (CFG):
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