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Glycosciences.DB structure entry #149: 3'-Sialyl-LewisX tetrasaccharide (beta-anomeric form)
a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc
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a-L-Fucp-(1-3)+
[][B-D-GLCPNAC]{[(3+1)][A-L-FUCP]{}[(4+1)][B-D-GALP]{[(3+2)][A-D-NEUP5AC]{}}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-dgro-dgal-NON-2:6|1:a|2:keto|3:d
6s:n-acetyl
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(3+2)5d
5:5d(5+1)6n
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="4" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="5" anomer="a" superclass="non" ringStart="2" ringEnd="6" name="a-dgro-dgal-NON-2:6|1:a|2:keto|3:d">
<stemtype id="1" type="dgro" />
<stemtype id="2" type="dgal" />
<modification type="a" pos_one="1" />
<modification type="keto" pos_one="2" />
<modification type="d" pos_one="3" />
</basetype>
<substituent id="6" name="n-acetyl" />
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="1" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
<connection id="4" parent="4" child="5">
<linkage id="4" parentType="o" childType="d">
<parent pos="3" />
<child pos="2" />
</linkage>
</connection>
<connection id="5" parent="5" child="6">
<linkage id="5" parentType="d" childType="n">
<parent pos="5" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>

1 - 5 of 13 entries with matching glycan part

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)+
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b-D-GlcpNAc-(1-5)-5-hydroxy-hexanoate-(1-1)-Methyl
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a-L-Fucp-(1-3)+
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Taxons |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)+
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b-D-GlcpNAc-(1-3)-<rest of molecule>
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a-L-Fucp-(1-3)+
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Taxons: 2 |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)+
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b-D-GlcpNAc-(1-1)-Allyl
|
a-L-Fucp-(1-3)+
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Taxons |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-4)-Asn-(1-2)-Gly-(1-2)-Phe
|
a-L-Fucp-(1-3)+
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Taxons |

a-D-Neup5Ac-(2-3)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-ethanolamine
|
a-L-Fucp-(1-3)+
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Taxons |
- Sialyl Lewis X (Show) (Search Database)
- SSEA-1
- SSEA1
- stage-specific embryonic antigen 1
- sLeX
- Sialyl Lewis X
- 3'sLex
- Sia-LeX
- 3'Sia-LeX
Chemical Formula: | C31H52N2O23 | #C | #H | #O | #N | |
Molec. Weight: | 820 | 31 | 52 | 23 | 2 | |
# Atoms: | 108 | |||||
# Residues: | 4 | |||||
# Heavy Atoms: | 56 |
Superclasses:
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Residues:
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1 - 5 of 8 PDB entries

PDB ID 5kiq:
SrpA with sialyl LewisX
Description: Platelet-binding glycoprotein
Source: Streptococcus sanguinis (strain SK36)
Experimental method: X-RAY DIFFRACTION
Resolution: 1.638Å
Release date: 2017-05-24
Entry features 1 distinct glycan structures [1 instances].

PDB ID 4uso:
X-ray structure of the CCL2 lectin in complex with sialyl lewis X
Description: CCL2 LECTIN
Source: COPRINOPSIS CINEREA
Experimental method: X-RAY DIFFRACTION
Resolution: 1.95Å
Release date: 2015-07-22
Entry features 1 distinct glycan structures [1 instances].

PDB ID 4rfb:
1.93 Angstrom Crystal Structure of Superantigen-like Protein from Staphylococcus aureus in Complex with Sialyl-Lewis X.
Description: Putative uncharacterized protein
Source: Staphylococcus aureus subsp. aureus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.93Å
Release date: 2014-10-08
Entry features 1 distinct glycan structures [4 instances].

PDB ID 4uo2:
Structure of the A_Equine_Richmond_07 H3 haemagglutinin in complex with Sialyl Lewis X
Description: H3 HAEMAGGLUTININ HA1 CHAIN, H3 HAEMAGGLUTININ HA2 CHAIN
Source:
Experimental method: X-RAY DIFFRACTION
Resolution: 2.7Å
Release date: 2014-07-23
Entry features 10 distinct glycan structures [25 instances].

PDB ID 2r61:
Crystal structure of the Staphylococcal superantigen-like protein SSL5 in complex with sialyl-Lewis X at pH 7.4
Description: Exotoxin 3
Source: Staphylococcus aureus
Experimental method: X-RAY DIFFRACTION
Resolution: 2.75Å
Release date: 2007-11-27
Entry features 1 distinct glycan structures [1 instances].
1 - 5 of 231 literature references

Reference #22043
Bleuler-Martinez S; Varrot A; Olieric V; Schubert M; Vogt E; Fetz C; Wohlschlager T; Plaza DF; Wälti M; Duport Y; Capitani G; Aebi M; Künzler M
Structure-function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity.
Published 2022 in Glycobiology, 32: 600-615
Reference contains 27 structures

Reference #21785
Walker MR; Goel HL; Mukhopadhyay D; Chhoy P; Karner ER; Clark JL; Liu H; Li R; Zhu JL; Chen S; Mahal LK; Bensing BA; Mercurio AM
O-linked α2,3 sialylation defines stem cell populations in breast cancer.
Published 2022 in Sci Adv, 8: eabj9513
Reference contains 5 structures

Reference #21703
Ezeabikwa B; Mondal N; Antonopoulos A; Haslam SM; Matsumoto Y; Martin-Caraballo M; Lehoux S; Mandalasi M; Ishaque A; Heimburg-Molinaro J; Cummings RD; Nyame AK
Major differences in glycosylation and fucosyltransferase expression in low-grade versus high-grade bladder cancer cell lines.
Published 2021 in Glycobiology, 31: 1444-1463
Reference contains 15 structures

Reference #22000
Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.
Published 2021 in Nat Chem Biol, 17: 806-816
Reference contains 65 structures

Reference #21602
Hyun JY; Kim S; Lee CH; Lee HS; Shin I
Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins.
Published 2021 in ACS Chem Biol, 16: 1930-1940
Reference contains 9 structures
1 - 3 of 3 literature references from PDB entries

Reference #20156
Loukachevitch LV; Bensing BA; Yu H; Zeng J; Chen X; Sullam PM; Iverson TM
Structures of the Streptococcus sanguinis SrpA Binding Region with Human Sialoglycans Suggest Features of the Physiological Ligand.
Published 2016 in Biochemistry, :

Reference #16968
Baker HM; Basu I; Chung MC; Caradoc-Davies T; Fraser JD; Baker EN
Crystal structures of the staphylococcal toxin SSL5 in complex with sialyl Lewis X reveal a conserved binding site that shares common features with viral and bacterial sialic acid binding proteins.
Published 2007 in J. Mol. Biol., 374: 1298-308

Reference #19806
Ng KK; Weis WI
Structure of a selectin-like mutant of mannose-binding protein complexed with sialylated and sulfated Lewis(x) oligosaccharides.
Published 1997 in Biochemistry, 36: 979-88
NCBI Taxonomy ID | Scientific Name |
10029 | Cricetulus griseus |
9031 | Gallus gallus |
9606 | Homo sapiens |
9544 | Macaca mulatta |
10090 | Mus musculus |
Consortium for Functional Glycomics (CFG):
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