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Glycosciences.DB structure entry #147: Blood group H Type 2 Glycan

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Format: CarbBank LINUCS GlycoCT_condensed GlycoCT_xml


 a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc


RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3o(2+1)4d


<?xml version="1.0" encoding="UTF-8"?>
 <sugar version="1.0">
 <residues>
 <basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
 <stemtype id="1" type="dglc" />
 </basetype>
 <substituent id="2" name="n-acetyl" />
 <basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
 <stemtype id="1" type="dgal" />
 </basetype>
 <basetype id="4" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
 <stemtype id="1" type="lgal" />
 <modification type="d" pos_one="6" />
 </basetype>
 </residues>
 <linkages>
 <connection id="1" parent="1" child="2">
 <linkage id="1" parentType="d" childType="n">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="2" parent="1" child="3">
 <linkage id="2" parentType="o" childType="d">
 <parent pos="4" />
 <child pos="1" />
 </linkage>
 </connection>
 <connection id="3" parent="3" child="4">
 <linkage id="3" parentType="o" childType="d">
 <parent pos="2" />
 <child pos="1" />
 </linkage>
 </connection>
 </linkages>
 </sugar>

SNFG-style Graphics

3D Structure Model

download coordinates

Corresponding entries: 14

1 - 5 of 14 entries with matching glycan part

Structure entry #283:

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)-Asn

NMR spectra

literature references

no GlycoMaps

Structure entry #371:

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl

no 3d model

NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #1710:

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Hexanolamine

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #2035:

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-<linker-TMR>

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #2545:

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-?-3-en-4-deoxy-Hex-ol

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Lactosamine (Show) (Search Database)
Blood Group H Antigen (Show) (Search Database)

Blood group H Type 2
BGH type 2
H Antigen Type 2

Type 2 H antigen
ABO blood group antigen

General Structure Data

Chemical Formula:	C₂₀H₃₅N₁O₁₅		#C	#H	#O	#N
Molec. Weight:	529		20	35	15	1
# Atoms:	71
# Residues:	3
# Heavy Atoms:	36

Superclasses:

Hex
Hex	1
dHex	1
HexNAc	1

Residues:

Residue	Count
A-L-FUCP	1
B-D-GALP	1
B-D-GLCPNAC	1

PDB references: 8

1 - 5 of 8 PDB entries

PDB ID 4d4u: Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) in complex with LewisY tetrasaccharide.

Description: FUCOSE-SPECIFIC LECTIN FLEA

Source: ASPERGILLUS FUMIGATUS

Experimental method: X-RAY DIFFRACTION

Resolution: 1.99Å

Release date: 2015-03-11

Entry features 4 distinct glycan structures [10 instances].

PDB ID 4p1v: Structure of the P domain from a GI.7 Norovirus variant in complex with H-type 2 HBGA

Description: Major capsid protein

Source: Norovirus Hu/GI.7/TCH-060/USA/2003

Experimental method: X-RAY DIFFRACTION

Resolution: 1.5497Å

Release date: 2014-04-02

Entry features 1 distinct glycan structures [4 instances].

PDB ID 3zzv: BambL complexed with Htype2 tetrasaccharide

Description: BAMBL LECTIN

Source: BURKHOLDERIA AMBIFARIA

Experimental method: X-RAY DIFFRACTION

Resolution: 1.68Å

Release date: 2011-12-21

Entry features 2 distinct glycan structures [6 instances].

PDB ID 2j1v: STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE IN COMPLEX WITH THE BLOOD GROUP H-TRISACCHARIDE

Description: FUCOLECTIN-RELATED PROTEIN

Source: STREPTOCOCCUS PNEUMONIAE

Experimental method: X-RAY DIFFRACTION

Resolution: 1.45Å

Release date: 2006-09-06

Entry features 1 distinct glycan structures [1 instances].

PDB ID 1uld: CGL2 in complex with blood group H type II

Description: galectin-2

Source: Coprinopsis cinerea

Experimental method: X-RAY DIFFRACTION

Resolution: 2.1Å

Release date: 2004-04-20

Entry features 1 distinct glycan structures [4 instances].

Conformational maps: 2

Map ID: 9388

Disaccharide Fragment: a-L-Fucp-(1-2)-b-D-Galp

Linkage Path: 42

Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Map ID: 9389

Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc

Linkage Path: 4

Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Literature references: 47

1 - 5 of 47 literature references

Reference #21992

Blenda AV; Kamili NA; Wu SC; Abel WF; Ayona D; Gerner-Smidt C; Ho AD; Benian GM; Cummings RD; Arthur CM; Stowell SR

Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group-like antigens.

Published 2022 in J Biol Chem, 298: 101704

Reference contains 42 structures

Reference #21957

Montesino B; Steenackers A; Lozano JM; Young GD; Hu N; Sackstein R; Chandler KB

Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma.

Published 2022 in Glycobiology, 32: 441-455

Reference contains 4 structures

Reference #21602

Hyun JY; Kim S; Lee CH; Lee HS; Shin I

Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins.

Published 2021 in ACS Chem Biol, 16: 1930-1940

Reference contains 9 structures

Reference #21998

Wang S; Chen C; Gadi MR; Saikam V; Liu D; Zhu H; Bollag R; Liu K; Chen X; Wang F; Wang PG; Ling P; Guan W; Li L

Chemoenzymatic modular assembly of O-GalNAc glycans for functional glycomics.

Published 2021 in Nat Commun, 12: 3573

Reference contains 51 structures

Reference #22000

Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R

Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.

Published 2021 in Nat Chem Biol, 17: 806-816

Reference contains 65 structures

Further literature references from PDB entries: 6

1 - 5 of 6 literature references from PDB entries

Reference #20334

Collins BC; Gunn RJ; McKitrick TR; Cummings RD; Cooper MD; Herrin BR; Wilson IA

Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates.

Published 2017 in Structure, :

Reference #19144

Houser J; Komarek J; Cioci G; Varrot A; Imberty A; Wimmerova M

Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent.

Published 2015 in Acta Crystallogr. D Biol. Crystallogr., 71: 442-53

Reference #18827

Shanker S; Czako R; Sankaran B; Atmar RL; Estes MK; Prasad BV

Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.

Published 2014 in J. Virol., 88: 6168-80

Reference #18053

Audfray A; Claudinon J; Abounit S; Ruvoën-Clouet N; Larson G; Smith DF; Wimmerová M; Le Pendu J; Römer W; Varrot A; Imberty A

Fucose-binding lectin from opportunistic pathogen Burkholderia ambifaria binds to both plant and human oligosaccharidic epitopes.

Published 2012 in J. Biol. Chem., 287: 4335-47

Reference #16714

Boraston AB; Wang D; Burke RD

Blood group antigen recognition by a Streptococcus pneumoniae virulence factor.

Published 2006 in J. Biol. Chem., 281: 35263-71

NCBI Taxonomy ID	Scientific Name
9606	Homo sapiens
9986	Oryctolagus cuniculus
10114	Rattus

Consortium for Functional Glycomics (CFG):

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