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Glycosciences.DB structure entry #147: Blood group H Type 2 Glycan
a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc
[][B-D-GLCPNAC]{[(4+1)][B-D-GALP]{[(2+1)][A-L-FUCP]{}}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:b-dgal-HEX-1:5
4b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(4+1)3d
3:3o(2+1)4d
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="4" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="3" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>

1 - 5 of 14 entries with matching glycan part

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-4)-Asn
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Taxons: 1 |

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
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Taxons |

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-Hexanolamine
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Taxons |

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-<linker-TMR>
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Taxons |

a-L-Fucp-(1-2)-b-D-Galp-(1-4)-b-D-GlcpNAc-(1-1)-?-3-en-4-deoxy-Hex-ol
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Taxons |
- Lactosamine (Show) (Search Database)
- Blood Group H Antigen (Show) (Search Database)
- Blood group H Type 2
- BGH type 2
- H Antigen Type 2
- Type 2 H antigen
- ABO blood group antigen
Chemical Formula: | C20H35N1O15 | #C | #H | #O | #N | |
Molec. Weight: | 529 | 20 | 35 | 15 | 1 | |
# Atoms: | 71 | |||||
# Residues: | 3 | |||||
# Heavy Atoms: | 36 |
Superclasses:
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Residues:
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1 - 5 of 8 PDB entries

PDB ID 4d4u:
Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) in complex with LewisY tetrasaccharide.
Description: FUCOSE-SPECIFIC LECTIN FLEA
Source: ASPERGILLUS FUMIGATUS
Experimental method: X-RAY DIFFRACTION
Resolution: 1.99Å
Release date: 2015-03-11
Entry features 4 distinct glycan structures [10 instances].

PDB ID 4p1v:
Structure of the P domain from a GI.7 Norovirus variant in complex with H-type 2 HBGA
Description: Major capsid protein
Source: Norovirus Hu/GI.7/TCH-060/USA/2003
Experimental method: X-RAY DIFFRACTION
Resolution: 1.5497Å
Release date: 2014-04-02
Entry features 1 distinct glycan structures [4 instances].

PDB ID 3zzv:
BambL complexed with Htype2 tetrasaccharide
Description: BAMBL LECTIN
Source: BURKHOLDERIA AMBIFARIA
Experimental method: X-RAY DIFFRACTION
Resolution: 1.68Å
Release date: 2011-12-21
Entry features 2 distinct glycan structures [6 instances].

PDB ID 2j1v:
STRUCTURE OF A STREPTOCOCCUS PNEUMONIAE FUCOSE BINDING MODULE IN COMPLEX WITH THE BLOOD GROUP H-TRISACCHARIDE
Description: FUCOLECTIN-RELATED PROTEIN
Source: STREPTOCOCCUS PNEUMONIAE
Experimental method: X-RAY DIFFRACTION
Resolution: 1.45Å
Release date: 2006-09-06
Entry features 1 distinct glycan structures [1 instances].

PDB ID 1uld:
CGL2 in complex with blood group H type II
Description: galectin-2
Source: Coprinopsis cinerea
Experimental method: X-RAY DIFFRACTION
Resolution: 2.1Å
Release date: 2004-04-20
Entry features 1 distinct glycan structures [4 instances].

Map ID: 9388
Disaccharide Fragment: a-L-Fucp-(1-2)-b-D-Galp
Linkage Path: 42
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns

Map ID: 9389
Disaccharide Fragment: b-D-Galp-(1-4)-b-D-GlcpNAc
Linkage Path: 4
Method: MD MM3(1996) Tinker 4 HTMD, 1000K, 30ns
1 - 5 of 49 literature references

Reference #21992
Blenda AV; Kamili NA; Wu SC; Abel WF; Ayona D; Gerner-Smidt C; Ho AD; Benian GM; Cummings RD; Arthur CM; Stowell SR
Galectin-9 recognizes and exhibits antimicrobial activity toward microbes expressing blood group-like antigens.
Published 2022 in J Biol Chem, 298: 101704
Reference contains 42 structures

Reference #22029
Klarić TS; Lauc G
The dynamic brain N-glycome.
Published 2022 in Glycoconj J, 39: 443-471
Reference contains 18 structures

Reference #22043
Bleuler-Martinez S; Varrot A; Olieric V; Schubert M; Vogt E; Fetz C; Wohlschlager T; Plaza DF; Wälti M; Duport Y; Capitani G; Aebi M; Künzler M
Structure-function relationship of a novel fucoside-binding fruiting body lectin from Coprinopsis cinerea exhibiting nematotoxic activity.
Published 2022 in Glycobiology, 32: 600-615
Reference contains 27 structures

Reference #21957
Montesino B; Steenackers A; Lozano JM; Young GD; Hu N; Sackstein R; Chandler KB
Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma.
Published 2022 in Glycobiology, 32: 441-455
Reference contains 4 structures

Reference #21602
Hyun JY; Kim S; Lee CH; Lee HS; Shin I
Efficient Preparation and Bioactivity Evaluation of Glycan-Defined Glycoproteins.
Published 2021 in ACS Chem Biol, 16: 1930-1940
Reference contains 9 structures
1 - 5 of 6 literature references from PDB entries

Reference #20334
Collins BC; Gunn RJ; McKitrick TR; Cummings RD; Cooper MD; Herrin BR; Wilson IA
Structural Insights into VLR Fine Specificity for Blood Group Carbohydrates.
Published 2017 in Structure, :

Reference #19144
Houser J; Komarek J; Cioci G; Varrot A; Imberty A; Wimmerova M
Structural insights into Aspergillus fumigatus lectin specificity: AFL binding sites are functionally non-equivalent.
Published 2015 in Acta Crystallogr. D Biol. Crystallogr., 71: 442-53

Reference #18827
Shanker S; Czako R; Sankaran B; Atmar RL; Estes MK; Prasad BV
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Published 2014 in J. Virol., 88: 6168-80

Reference #18053
Audfray A; Claudinon J; Abounit S; Ruvoën-Clouet N; Larson G; Smith DF; Wimmerová M; Le Pendu J; Römer W; Varrot A; Imberty A
Fucose-binding lectin from opportunistic pathogen Burkholderia ambifaria binds to both plant and human oligosaccharidic epitopes.
Published 2012 in J. Biol. Chem., 287: 4335-47

Reference #16714
Boraston AB; Wang D; Burke RD
Blood group antigen recognition by a Streptococcus pneumoniae virulence factor.
Published 2006 in J. Biol. Chem., 281: 35263-71
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