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Glycosciences.DB structure entry #142: Glycosphingolipid GM1 / GM1a


 b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+
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                            b-D-Galp-(1-4)-b-D-Glcp-(1-1)-Ceramide
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                a-D-Neup5Ac-(2-3)+

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Corresponding entries: 22

1 - 5 of 22 entries with matching glycan part

Structure entry #765:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-<2-D-erythro-2-acetamide-octadec-4E-en-1,3-diol> | a-D-Neup5Ac-(2-3)+

: 2

Taxons

Structure entry #766:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-sphingosine-(2-1)-<2-chloroacetate> | a-D-Neup5Ac-(2-3)+

: 5

Taxons

Structure entry #2677:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp | a-D-Neup5Ac-(2-3)+

: 13

: 97

Taxons

Structure entry #2875:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-hexyl | a-D-Neup5Ac-(2-3)+

: 1

Taxons

Structure entry #3946:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-2R-amino-Octadec-4E-en-1,3S-diol | a-D-Neup5Ac-(2-3)+

GSL core, ganglio-type (Show) (Search Database)
GM1a (Show) (Search Database)

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Trivial names

GM1
GM1a
II3Neu5AcGg4Cer

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Keywords

glycosphingolipid

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General Structure Data

Chemical Formula:	C₇₀H₁₂₅N₃O₃₁	#C	#H	#O	#N
Molec. Weight:	1504	70	125	31	3
# Atoms:	229
# Residues:	6
# Heavy Atoms:	104

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Composition

Superclasses:

Neu		Hex
NeuAc	1	Hex	3
		HexNAc	1

Residues:

Residue	Count
A-D-NEUP5AC	1
B-D-GALP	2
B-D-GALPNAC	1
B-D-GLCP	1
CERAMIDE	1

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NMR Carbon Chemical Shift Info

MHz	0
Temperature	0
Solvent	D2O
Residue	Linkage	Carbon	PPM	JFrom	JTo	Hz	Note
b-D-Glcp	1,4,1	C1	103.40			0
b-D-Glcp	1,4,1	C2	74.10			0
b-D-Glcp	1,4,1	C3	75.20			0
b-D-Glcp	1,4,1	C4	79.80			0
b-D-Glcp	1,4,1	C5	75.70			0
b-D-Glcp	1,4,1	C6	61.00			0
b-D-Galp	4,1,4,1	C1	103.40			0
b-D-Galp	4,1,4,1	C2	70.70			0
b-D-Galp	4,1,4,1	C3	75.20			0
b-D-Galp	4,1,4,1	C4	78.10			0
b-D-Galp	4,1,4,1	C5	75.00			0
b-D-Galp	4,1,4,1	C6	61.80			0
b-D-GalpNAc	4,4,1,4,1	C1	103.40			0
b-D-GalpNAc	4,4,1,4,1	C2	52.80			0
b-D-GalpNAc	4,4,1,4,1	C3	81.50			0
b-D-GalpNAc	4,4,1,4,1	C4	68.80			0
b-D-GalpNAc	4,4,1,4,1	C5	75.70			0
b-D-GalpNAc	4,4,1,4,1	C6	61.40			0
b-D-Galp	3,4,4,1,4,1	C1	105.60			0
b-D-Galp	3,4,4,1,4,1	C2	71.70			0
b-D-Galp	3,4,4,1,4,1	C3	73.60			0
b-D-Galp	3,4,4,1,4,1	C4	69.20			0
b-D-Galp	3,4,4,1,4,1	C5	75.70			0
b-D-Galp	3,4,4,1,4,1	C6	61.40			0
a-D-Neup5Ac	3,4,1,4,1	C1	174.50			0
a-D-Neup5Ac	3,4,1,4,1	C2	102.50			0
a-D-Neup5Ac	3,4,1,4,1	C3	37.80			0
a-D-Neup5Ac	3,4,1,4,1	C4	69.20			0
a-D-Neup5Ac	3,4,1,4,1	C5	52.00			0
a-D-Neup5Ac	3,4,1,4,1	C6	73.60			0
a-D-Neup5Ac	3,4,1,4,1	C7	69.20			0
a-D-Neup5Ac	3,4,1,4,1	C8	72.90			0
a-D-Neup5Ac	3,4,1,4,1	C9	64.00			0

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PDB references: 1

1 - 1 of 1 PDB entries

PDB ID 5j7z: Crystal structure of endoglycoceramidase I from Rhodococ-cus equi in complex with GM1

Description: Putative secreted endoglycosylceramidase

Source: Rhodococcus equi 103S

Experimental method: X-RAY DIFFRACTION

Resolution: 2.15Å

Release date: 2016-04-27

Entry features 1 distinct glycan structures [1 instances].

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Literature references: 632

1 - 5 of 632 literature references

Reference #21320

Di Biase E; Lunghi G; Fazzari M; Maggioni M; Pomè DY; Valsecchi M; Samarani M; Fato P; Ciampa MG; Prioni S; Mauri L; Sonnino S; Chiricozzi E

Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide.

Published 2020 in Glycoconj. J., :

Reference contains 2 structures

Reference #21331

Indellicato R; Domenighini R; Malagolini N; Cereda A; Mamoli D; Pezzani L; Iascone M; dall'Olio F; Trinchera M

A novel nonsense and inactivating variant of ST3GAL3 in two infant siblings suffering severe epilepsy and expressing circulating CA19.9.

Published 2020 in Glycobiology, 30: 95-104

Reference contains 6 structures

Reference #21336

Di Biase E; Lunghi G; Maggioni M; Fazzari M; Pomè DY; Loberto N; Ciampa MG; Fato P; Mauri L; Sevin E; Gosselet F; Sonnino S; Chiricozzi E

GM1 Oligosaccharide Crosses the Human Blood-Brain Barrier In Vitro by a Paracellular Route.

Published 2020 in Int J Mol Sci, 21:

Reference contains 2 structures

Reference #20740

Dunn TM; Tifft CJ; Proia RL

A perilous path: the inborn errors of sphingolipid metabolism.

Published 2019 in J. Lipid Res., 60: 475-483

Reference contains 9 structures

Reference #21161

Akintayo A; Stanley P

Roles for Golgi Glycans in Oogenesis and Spermatogenesis.

Published 2019 in Front Cell Dev Biol, 7: 98

Reference contains 30 structures

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Taxonomy: 20

NCBI Taxonomy ID	Scientific Name
9913	Bos taurus
7957	Carassius auratus
10141	Cavia porcellus
10150	Chinchillidae
8113	Cichlidae
10026	Cricetinae
10029	Cricetulus griseus
9685	Felis catus
9031	Gallus gallus
9606	Homo sapiens
9542	Macaca fuscata
9544	Macaca mulatta
10090	Mus musculus
9986	Oryctolagus cuniculus
9940	Ovis aries
9557	Papio hamadryas
10114	Rattus
9376	Soricidae
9823	Sus scrofa
9739	Tursiops truncatus

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Crosslinks: 2

Consortium for Functional Glycomics (CFG):

carbGlipid_21020_D000

GlycoEpitope DB:

EP0050

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Glycosciences.DB structure entry #142: Glycosphingolipid GM1 / GM1a

1 - 5 of 22 entries with matching glycan part

1 - 1 of 1 PDB entries

1 - 5 of 632 literature references

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