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Glycosciences.DB structure entry #142: Glycosphingolipid GM1 / GM1a


 b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+
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                            b-D-Galp-(1-4)-b-D-Glcp-(1-1)-Ceramide
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                a-D-Neup5Ac-(2-3)+

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Corresponding entries: 22

1 - 5 of 22 entries with matching glycan part

Structure entry #765:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-<2-D-erythro-2-acetamide-octadec-4E-en-1,3-diol> | a-D-Neup5Ac-(2-3)+

: 2

Taxons

Structure entry #766:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-sphingosine-(2-1)-<2-chloroacetate> | a-D-Neup5Ac-(2-3)+

: 5

Taxons

Structure entry #2677:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp | a-D-Neup5Ac-(2-3)+

: 15

: 101

Taxons

Structure entry #2875:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-hexyl | a-D-Neup5Ac-(2-3)+

: 1

Taxons

Structure entry #3946:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-2R-amino-Octadec-4E-en-1,3S-diol | a-D-Neup5Ac-(2-3)+

GSL core, ganglio-type (Show) (Search Database)
GM1a (Show) (Search Database)

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Trivial names

GM1
GM1a
II3Neu5AcGg4Cer

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Keywords

glycosphingolipid

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General Structure Data

Chemical Formula:	C₇₀H₁₂₅N₃O₃₁	#C	#H	#O	#N
Molec. Weight:	1504	70	125	31	3
# Atoms:	229
# Residues:	6
# Heavy Atoms:	104

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Composition

Superclasses:

Neu		Hex
NeuAc	1	Hex	3
		HexNAc	1

Residues:

Residue	Count
A-D-NEUP5AC	1
B-D-GALP	2
B-D-GALPNAC	1
B-D-GLCP	1
CERAMIDE	1

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NMR Carbon Chemical Shift Info

MHz	0
Temperature	0
Solvent	D2O
Residue	Linkage	Carbon	PPM	JFrom	JTo	Hz	Note
b-D-Glcp	1,4,1	C1	103.40			0
b-D-Glcp	1,4,1	C2	74.10			0
b-D-Glcp	1,4,1	C3	75.20			0
b-D-Glcp	1,4,1	C4	79.80			0
b-D-Glcp	1,4,1	C5	75.70			0
b-D-Glcp	1,4,1	C6	61.00			0
b-D-Galp	4,1,4,1	C1	103.40			0
b-D-Galp	4,1,4,1	C2	70.70			0
b-D-Galp	4,1,4,1	C3	75.20			0
b-D-Galp	4,1,4,1	C4	78.10			0
b-D-Galp	4,1,4,1	C5	75.00			0
b-D-Galp	4,1,4,1	C6	61.80			0
b-D-GalpNAc	4,4,1,4,1	C1	103.40			0
b-D-GalpNAc	4,4,1,4,1	C2	52.80			0
b-D-GalpNAc	4,4,1,4,1	C3	81.50			0
b-D-GalpNAc	4,4,1,4,1	C4	68.80			0
b-D-GalpNAc	4,4,1,4,1	C5	75.70			0
b-D-GalpNAc	4,4,1,4,1	C6	61.40			0
b-D-Galp	3,4,4,1,4,1	C1	105.60			0
b-D-Galp	3,4,4,1,4,1	C2	71.70			0
b-D-Galp	3,4,4,1,4,1	C3	73.60			0
b-D-Galp	3,4,4,1,4,1	C4	69.20			0
b-D-Galp	3,4,4,1,4,1	C5	75.70			0
b-D-Galp	3,4,4,1,4,1	C6	61.40			0
a-D-Neup5Ac	3,4,1,4,1	C1	174.50			0
a-D-Neup5Ac	3,4,1,4,1	C2	102.50			0
a-D-Neup5Ac	3,4,1,4,1	C3	37.80			0
a-D-Neup5Ac	3,4,1,4,1	C4	69.20			0
a-D-Neup5Ac	3,4,1,4,1	C5	52.00			0
a-D-Neup5Ac	3,4,1,4,1	C6	73.60			0
a-D-Neup5Ac	3,4,1,4,1	C7	69.20			0
a-D-Neup5Ac	3,4,1,4,1	C8	72.90			0
a-D-Neup5Ac	3,4,1,4,1	C9	64.00			0

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PDB references: 1

1 - 1 of 1 PDB entries

PDB ID 5j7z: Crystal structure of endoglycoceramidase I from Rhodococ-cus equi in complex with GM1

Description: Putative secreted endoglycosylceramidase

Source: Rhodococcus equi 103S

Experimental method: X-RAY DIFFRACTION

Resolution: 2.15Å

Release date: 2016-04-27

Entry features 1 distinct glycan structures [1 instances].

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Literature references: 659

1 - 5 of 659 literature references

Reference #21960

Yahi N; Di Scala C; Chahinian H; Fantini J

Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson's disease.

Published 2022 in Glycoconj J, 39: 1-11

Reference contains 2 structures

Reference #21963

Wallom KL; Fernández-Suárez ME; Priestman DA; Te Vruchte D; Huebecker M; Hallett PJ; Isacson O; Platt FM

Glycosphingolipid metabolism and its role in ageing and Parkinson's disease.

Published 2022 in Glycoconj J, 39: 39-53

Reference contains 6 structures

Reference #21966

Chiricozzi E

Plasma membrane glycosphingolipid signaling: a turning point.

Published 2022 in Glycoconj J, 39: 99-105

Reference contains 3 structures

Reference #21970

He X; Guan F; Lei L

Structure and function of glycosphingolipids on small extracellular vesicles.

Published 2022 in Glycoconj J, 39: 197-205

Reference contains 8 structures

Reference #22496

Santos RCM; Lucena DMS; Loponte HFBR; Alisson-Silva F; Dias WB; Lins RD; Todeschini AR

GM2/GM3 controls the organizational status of CD82/Met microdomains: further studies in GM2/GM3 complexation.

Published 2022 in Glycoconj J, 39: 653-661

Reference contains 4 structures

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Taxonomy: 20

NCBI Taxonomy ID	Scientific Name
9913	Bos taurus
7957	Carassius auratus
10141	Cavia porcellus
10150	Chinchillidae
8113	Cichlidae
10026	Cricetinae
10029	Cricetulus griseus
9685	Felis catus
9031	Gallus gallus
9606	Homo sapiens
9542	Macaca fuscata
9544	Macaca mulatta
10090	Mus musculus
9986	Oryctolagus cuniculus
9940	Ovis aries
9557	Papio hamadryas
10114	Rattus
9376	Soricidae
9823	Sus scrofa
9739	Tursiops truncatus

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Crosslinks: 2

Consortium for Functional Glycomics (CFG):

carbGlipid_21020_D000

GlycoEpitope DB:

EP0050

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Glycosciences.DB structure entry #142: Glycosphingolipid GM1 / GM1a

1 - 5 of 22 entries with matching glycan part

1 - 1 of 1 PDB entries

1 - 5 of 659 literature references

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