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Glycosciences.DB structure entry #142: Glycosphingolipid GM1 / GM1a


 b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+
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                            b-D-Galp-(1-4)-b-D-Glcp-(1-1)-Ceramide
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                a-D-Neup5Ac-(2-3)+

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Corresponding entries: 22

1 - 5 of 22 entries with matching glycan part

Structure entry #765:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-<2-D-erythro-2-acetamide-octadec-4E-en-1,3-diol> | a-D-Neup5Ac-(2-3)+

: 2

Taxons

Structure entry #766:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-sphingosine-(2-1)-<2-chloroacetate> | a-D-Neup5Ac-(2-3)+

: 5

Taxons

Structure entry #2677:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp | a-D-Neup5Ac-(2-3)+

: 13

: 101

Taxons

Structure entry #2875:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-hexyl | a-D-Neup5Ac-(2-3)+

: 1

Taxons

Structure entry #3946:

b-D-Galp-(1-3)-b-D-GalpNAc-(1-4)+ | b-D-Galp-(1-4)-b-D-Glcp-(1-1)-2R-amino-Octadec-4E-en-1,3S-diol | a-D-Neup5Ac-(2-3)+

GSL core, ganglio-type (Show) (Search Database)
GM1a (Show) (Search Database)

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Trivial names

GM1
GM1a
II3Neu5AcGg4Cer

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Keywords

glycosphingolipid

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General Structure Data

Chemical Formula:	C₇₀H₁₂₅N₃O₃₁	#C	#H	#O	#N
Molec. Weight:	1504	70	125	31	3
# Atoms:	229
# Residues:	6
# Heavy Atoms:	104

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Composition

Superclasses:

Neu		Hex
NeuAc	1	Hex	3
		HexNAc	1

Residues:

Residue	Count
A-D-NEUP5AC	1
B-D-GALP	2
B-D-GALPNAC	1
B-D-GLCP	1
CERAMIDE	1

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NMR Carbon Chemical Shift Info

MHz	0
Temperature	0
Solvent	D2O
Residue	Linkage	Carbon	PPM	JFrom	JTo	Hz	Note
b-D-Glcp	1,4,1	C1	103.40			0
b-D-Glcp	1,4,1	C2	74.10			0
b-D-Glcp	1,4,1	C3	75.20			0
b-D-Glcp	1,4,1	C4	79.80			0
b-D-Glcp	1,4,1	C5	75.70			0
b-D-Glcp	1,4,1	C6	61.00			0
b-D-Galp	4,1,4,1	C1	103.40			0
b-D-Galp	4,1,4,1	C2	70.70			0
b-D-Galp	4,1,4,1	C3	75.20			0
b-D-Galp	4,1,4,1	C4	78.10			0
b-D-Galp	4,1,4,1	C5	75.00			0
b-D-Galp	4,1,4,1	C6	61.80			0
b-D-GalpNAc	4,4,1,4,1	C1	103.40			0
b-D-GalpNAc	4,4,1,4,1	C2	52.80			0
b-D-GalpNAc	4,4,1,4,1	C3	81.50			0
b-D-GalpNAc	4,4,1,4,1	C4	68.80			0
b-D-GalpNAc	4,4,1,4,1	C5	75.70			0
b-D-GalpNAc	4,4,1,4,1	C6	61.40			0
b-D-Galp	3,4,4,1,4,1	C1	105.60			0
b-D-Galp	3,4,4,1,4,1	C2	71.70			0
b-D-Galp	3,4,4,1,4,1	C3	73.60			0
b-D-Galp	3,4,4,1,4,1	C4	69.20			0
b-D-Galp	3,4,4,1,4,1	C5	75.70			0
b-D-Galp	3,4,4,1,4,1	C6	61.40			0
a-D-Neup5Ac	3,4,1,4,1	C1	174.50			0
a-D-Neup5Ac	3,4,1,4,1	C2	102.50			0
a-D-Neup5Ac	3,4,1,4,1	C3	37.80			0
a-D-Neup5Ac	3,4,1,4,1	C4	69.20			0
a-D-Neup5Ac	3,4,1,4,1	C5	52.00			0
a-D-Neup5Ac	3,4,1,4,1	C6	73.60			0
a-D-Neup5Ac	3,4,1,4,1	C7	69.20			0
a-D-Neup5Ac	3,4,1,4,1	C8	72.90			0
a-D-Neup5Ac	3,4,1,4,1	C9	64.00			0

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PDB references: 1

1 - 1 of 1 PDB entries

PDB ID 5j7z: Crystal structure of endoglycoceramidase I from Rhodococ-cus equi in complex with GM1

Description: Putative secreted endoglycosylceramidase

Source: Rhodococcus equi 103S

Experimental method: X-RAY DIFFRACTION

Resolution: 2.15Å

Release date: 2016-04-27

Entry features 1 distinct glycan structures [1 instances].

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Literature references: 658

1 - 5 of 658 literature references

Reference #21692

Uraki R; Kawaoka Y

Host glycolipids in SARS-CoV-2 entry.

Published 2022 in Nat Chem Biol, 18: 6-7

Reference contains 2 structures

Reference #21955

Zalem D; Juhás M; Terrinoni M; King-Lyons N; Lebens M; Varrot A; Connell TD; Teneberg S

Characterization of the ganglioside recognition profile of Escherichia coli heat-labile enterotoxin LT-IIc.

Published 2022 in Glycobiology, 32: 391-403

Reference contains 29 structures

Reference #21962

Fazzari M; Di Biase E; Lunghi G; Mauri L; Chiricozzi E; Sonnino S

Novel insights on GM1 and Parkinson's disease: A critical review.

Published 2022 in Glycoconj J, 39: 27-38

Reference contains 1 structure

Reference #21965

Ledeen R; Chowdhury S; Lu ZH; Chakraborty M; Wu G

Systemic deficiency of GM1 ganglioside in Parkinson's disease tissues and its relation to the disease etiology.

Published 2022 in Glycoconj J, 39: 75-82

Reference contains 2 structures

Reference #21969

Liang YJ

Glycosphingolipids in human embryonic stem cells and breast cancer stem cells, and potential cancer therapy strategies based on their structures and functions.

Published 2022 in Glycoconj J, 39: 177-195

Reference contains 21 structures

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Taxonomy: 20

NCBI Taxonomy ID	Scientific Name
9913	Bos taurus
7957	Carassius auratus
10141	Cavia porcellus
10150	Chinchillidae
8113	Cichlidae
10026	Cricetinae
10029	Cricetulus griseus
9685	Felis catus
9031	Gallus gallus
9606	Homo sapiens
9542	Macaca fuscata
9544	Macaca mulatta
10090	Mus musculus
9986	Oryctolagus cuniculus
9940	Ovis aries
9557	Papio hamadryas
10114	Rattus
9376	Soricidae
9823	Sus scrofa
9739	Tursiops truncatus

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Crosslinks: 2

Consortium for Functional Glycomics (CFG):

carbGlipid_21020_D000

GlycoEpitope DB:

EP0050

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Glycosciences.DB structure entry #142: Glycosphingolipid GM1 / GM1a

1 - 5 of 22 entries with matching glycan part

1 - 1 of 1 PDB entries

1 - 5 of 658 literature references

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