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Glycosciences.DB structure entry #134: Lactosylceramide / LacCer

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Format: CarbBank LINUCS


 b-D-Galp-(1-4)-b-D-Glcp-(1-1)-Ceramide

Corresponding entries: 55

1 - 5 of 55 entries with matching glycan part

Structure entry #325:

b-D-Galp-(1-4)-b-D-Glcp-(1-1)-Methyl

no 3d model

NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #1753:

b-D-Galp-(1-4)-b-D-Glcp-(1-1)-2-propenamide

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #2240:

b-D-Galp-(1-4)-b-D-Glcp-(1-5)-Gln-(1-2)-Tyr-(1-2)-Gly-(1-2)-Gly-(1-2)-Phe-(1-2)-Leu

no 3d model

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #3456:

b-D-Galp-(1-4)-b-D-Glcp-(1-1)-2R-amino-Octadec-4E-en-1,3S-diol

no NMR spectra

literature references

no GlycoMaps

Taxons

Structure entry #5958:

b-D-Galp-(1-4)-b-D-Glcp-(1-3)-Ser-(1-2)-Ile-(1-2)-Lys-(1-2)-Val-(1-2)-Ala-(1-2)-Val

no NMR spectra

literature references

no GlycoMaps

Taxons

lactosylceramide
LacCer
asialo-GM3

glycosphingolipid

General Structure Data

Chemical Formula:	C₄₅H₈₅N₁O₁₃		#C	#H	#O	#N
Molec. Weight:	848		45	85	13	1
# Atoms:	144
# Residues:	3
# Heavy Atoms:	59

Superclasses:

Hex
Hex	2

Residues:

Residue	Count
B-D-GALP	1
B-D-GLCP	1
CERAMIDE	1

PDB references: 1

1 - 1 of 1 PDB entries

PDB ID 5j14: Crystal structure of endoglycoceramidase I from Rhodococ-cus equi in complex with GM3

Description: Putative secreted endoglycosylceramidase

Source: Rhodococcus equi 103S

Experimental method: X-RAY DIFFRACTION

Resolution: 1.915Å

Release date: 2016-04-27

Entry features 2 distinct glycan structures [2 instances].

Literature references: 223

1 - 5 of 223 literature references

Reference #21338

Ramos RI; Bustos MA; Wu J; Jones P; Chang SC; Kiyohara E; Tran K; Zhang X; Stern SL; Izraely S; Sagi-Assif O; Witz IP; Davies MA; Mills GB; Kelly DF; Irie RF; Hoon DSB

Upregulation of Cell Surface GD3 Ganglioside Phenotype is Associated with Human Melanoma Brain Metastasis.

Published 2020 in Mol Oncol, :

Reference contains 5 structures

Reference #21588

Jennemann R; Kaden S; Volz M; Nordström V; Herzer S; Sandhoff R; Gröne HJ

Gangliosides modulate insulin secretion by pancreatic beta cells under glucose stress.

Published 2020 in Glycobiology, 30: 722-734

Reference contains 5 structures

Reference #21592

Sugawara S; Takayanagi M; Honda S; Tatsuta T; Fujii Y; Ozeki Y; Ito J; Sato M; Hosono AM

Catfish egg lectin affects influx and efflux rates of sunitinib in human cervical carcinoma HeLa cells.

Published 2020 in Glycobiology, 30: 802-816

Reference contains 3 structures

Reference #21159

Silsirivanit A; Phoomak C; Teeravirote K; Wattanavises S; Seubwai W; Saengboonmee C; Zhan Z; Inokuchi JI; Suzuki A; Wongkham S

Overexpression of HexCer and LacCer containing 2-hydroxylated fatty acids in cholangiocarcinoma and the association of the increase of LacCer (d18:1-h23:0) with shorter survival of the patients.

Published 2019 in Glycoconj. J., 36: 103-111

Reference contains 4 structures

Reference #21293

Legros N; Ptascheck S; Pohlentz G; Karch H; Dobrindt U; Müthing J

PapG subtype-specific binding characteristics of Escherichia coli towards globo-series glycosphingolipids of human kidney and bladder uroepithelial cells.

Published 2019 in Glycobiology, 29: 789-802

Reference contains 6 structures

NCBI Taxonomy ID	Scientific Name
7588	Asteroidea
9913	Bos taurus
9615	Canis familiaris
93934	Coturnix japonica
10029	Cricetulus griseus
9685	Felis catus
9031	Gallus gallus
9606	Homo sapiens
9544	Macaca mulatta
10090	Mus musculus
9986	Oryctolagus cuniculus
10114	Rattus
9823	Sus scrofa

Glyco-CD:

CD17

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