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Glycosciences.DB structure entry #1132: LewisY tetrasaccharide (beta-anomeric form)
a-L-Fucp-(1-2)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc
|
a-L-Fucp-(1-3)+
[][B-D-GLCPNAC]{[(3+1)][A-L-FUCP]{}[(4+1)][B-D-GALP]{[(2+1)][A-L-FUCP]{}}}
RES
1b:b-dglc-HEX-1:5
2s:n-acetyl
3b:a-lgal-HEX-1:5|6:d
4b:b-dgal-HEX-1:5
5b:a-lgal-HEX-1:5|6:d
LIN
1:1d(2+1)2n
2:1o(3+1)3d
3:1o(4+1)4d
4:4o(2+1)5d
<?xml version="1.0" encoding="UTF-8"?>
<sugar version="1.0">
<residues>
<basetype id="1" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dglc-HEX-1:5">
<stemtype id="1" type="dglc" />
</basetype>
<substituent id="2" name="n-acetyl" />
<basetype id="3" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
<basetype id="4" anomer="b" superclass="hex" ringStart="1" ringEnd="5" name="b-dgal-HEX-1:5">
<stemtype id="1" type="dgal" />
</basetype>
<basetype id="5" anomer="a" superclass="hex" ringStart="1" ringEnd="5" name="a-lgal-HEX-1:5|6:d">
<stemtype id="1" type="lgal" />
<modification type="d" pos_one="6" />
</basetype>
</residues>
<linkages>
<connection id="1" parent="1" child="2">
<linkage id="1" parentType="d" childType="n">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
<connection id="2" parent="1" child="3">
<linkage id="2" parentType="o" childType="d">
<parent pos="3" />
<child pos="1" />
</linkage>
</connection>
<connection id="3" parent="1" child="4">
<linkage id="3" parentType="o" childType="d">
<parent pos="4" />
<child pos="1" />
</linkage>
</connection>
<connection id="4" parent="4" child="5">
<linkage id="4" parentType="o" childType="d">
<parent pos="2" />
<child pos="1" />
</linkage>
</connection>
</linkages>
</sugar>
3D Structure Model1 - 5 of 13 entries with matching glycan part
Structure entry #373:
a-L-Fucp-(1-2)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-9)-9-hydroxy-Nonanoate-(1-1)-Methyl
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a-L-Fucp-(1-3)+
 |
 13C: 1 |
 |
 : 6 |
 |
Taxons |
Structure entry #2037:
a-L-Fucp-(1-2)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-<linker-TMR>
|
a-L-Fucp-(1-3)+
|
 |
|
: 1 |
|
Taxons |
Structure entry #2172: Lewis Y antigen, CD174
a-L-Fucp-(1-2)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-3)-<rest of molecule>
|
a-L-Fucp-(1-3)+
|
|
|
: 2 |
|
Taxons: 2 |
Structure entry #2546:
a-L-Fucp-(1-2)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-?-3-en-4-deoxy-Hex-ol
|
a-L-Fucp-(1-3)+
|
|
|
: 2 |
|
Taxons |
Structure entry #3805:
a-L-Fucp-(1-2)-b-D-Galp-(1-4)+
|
b-D-GlcpNAc-(1-1)-Hex-3-en-1,2,5,6-tetrol
|
a-L-Fucp-(1-3)+
|
|
|
: 1 |
|
Taxons |
- Lewis Y (Show) (Search Database)
| Chemical Formula: | C26H45N1O19 | #C | #H | #O | #N | |
| Molec. Weight: | 675 | 26 | 45 | 19 | 1 | |
| # Atoms: | 91 | |||||
| # Residues: | 4 | |||||
| # Heavy Atoms: | 46 | |||||
Superclasses:
|
Residues:
|
||||||||||||||||
PDB references: 71 - 5 of 7 PDB entries
PDB ID 5elc:
Cholera toxin El Tor B-pentamer in complex with Lewis-y
Description: Cholera enterotoxin subunit B
Source: Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Experimental method: X-RAY DIFFRACTION
Resolution: 1.5Å
Release date: 2016-03-30
Entry features 3 distinct glycan structures [10 instances].
PDB ID 4p25:
Structure of the P domain from a GI.7 Norovirus variant in complex with LeY HBGA.
Description: Major capsid protein
Source: Norovirus Hu/GI.7/TCH-060/USA/2003
Experimental method: X-RAY DIFFRACTION
Resolution: 1.4991Å
Release date: 2014-04-02
Entry features 1 distinct glycan structures [4 instances].
PDB ID 4gwi:
His 62 mutant of the lectin binding domain of lectinolysin complexed with Lewis y
Description: Platelet aggregation factor Sm-hPAF
Source: Streptococcus mitis
Experimental method: X-RAY DIFFRACTION
Resolution: 1.6Å
Release date: 2012-11-21
Entry features 1 distinct glycan structures [1 instances].
PDB ID 3pa2:
Crystal Structure of P Domain from Norwalk Virus Strain Vietnam 026 in complex with HBGA type Ley
Description: Capsid protein
Source: Norwalk virus
Experimental method: X-RAY DIFFRACTION
Resolution: 1.48Å
Release date: 2011-05-11
Entry features 1 distinct glycan structures [1 instances].
PDB ID 3leg:
Lectin Domain of Lectinolysin complexed with Lewis Y Antigen
Description: Platelet aggregation factor Sm-hPAF
Source: Streptococcus mitis
Experimental method: X-RAY DIFFRACTION
Resolution: 2.01Å
Release date: 2010-12-29
Entry features 1 distinct glycan structures [1 instances].
Literature references: 591 - 5 of 59 literature references
Reference #21957
Montesino B; Steenackers A; Lozano JM; Young GD; Hu N; Sackstein R; Chandler KB
Identification of α1,2-fucosylated signaling and adhesion molecules in head and neck squamous cell carcinoma.
Published 2022 in Glycobiology, 32: 441-455
Reference contains 4 structures
Reference #22000
Sojitra M; Sarkar S; Maghera J; Rodrigues E; Carpenter EJ; Seth S; Ferrer Vinals D; Bennett NJ; Reddy R; Khalil A; Xue X; Bell MR; Zheng RB; Zhang P; Nycholat C; Bailey JJ; Ling CC; Lowary TL; Paulson JC; Macauley MS; Derda R
Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage.
Published 2021 in Nat Chem Biol, 17: 806-816
Reference contains 65 structures
Reference #21814
Roderer D; Bröcker F; Sitsel O; Kaplonek P; Leidreiter F; Seeberger PH; Raunser S
Glycan-dependent cell adhesion mechanism of Tc toxins.
Published 2020 in Nat Commun, 11: 2694
Reference contains 13 structures
Reference #21053
Gutiérrez-Huante K; Salinas-Marín R; Mora-Montes HM; Gonzalez RA; Martínez-Duncker I
Human adenovirus type 5 increases host cell fucosylation and modifies Ley antigen expression.
Published 2019 in Glycobiology, 29: 469-478
Reference contains 3 structures
Reference #21006
Gonciarz W; Walencka M; Moran AP; Hinc K; Obuchowski M; Chmiela M
Upregulation of MUC5AC production and deposition of LEWIS determinants by HELICOBACTER PYLORI facilitate gastric tissue colonization and the maintenance of infection.
Published 2019 in J. Biomed. Sci., 26: 23
Reference contains 2 structures
1 - 5 of 7 literature references from PDB entries
Reference #19530
Heggelund JE; Burschowsky D; Bjørnestad VA; Hodnik V; Anderluh G; Krengel U
High-Resolution Crystal Structures Elucidate the Molecular Basis of Cholera Blood Group Dependence.
Published 2016 in PLoS Pathog., 12: e1005567
Reference #18827
Shanker S; Czako R; Sankaran B; Atmar RL; Estes MK; Prasad BV
Structural analysis of determinants of histo-blood group antigen binding specificity in genogroup I noroviruses.
Published 2014 in J. Virol., 88: 6168-80
Reference #18359
Lawrence SL; Feil SC; Holien JK; Kuiper MJ; Doughty L; Dolezal O; Mulhern TD; Tweten RK; Parker MW
Manipulating the Lewis antigen specificity of the cholesterol-dependent cytolysin lectinolysin.
Published 2012 in Front Immunol, 3: 330
Reference #18095
Feil SC; Lawrence S; Mulhern TD; Holien JK; Hotze EM; Farrand S; Tweten RK; Parker MW
Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
Published 2012 in Structure, 20: 248-58
Reference #17837
Hansman GS; Biertümpfel C; Georgiev I; McLellan JS; Chen L; Zhou T; Katayama K; Kwong PD
Crystal structures of GII.10 and GII.12 norovirus protruding domains in complex with histo-blood group antigens reveal details for a potential site of vulnerability.
Published 2011 in J. Virol., 85: 6687-701
| NCBI Taxonomy ID | Scientific Name |
| 9534 | Cercopithecus aethiops |
| 9606 | Homo sapiens |
| 12721 | Human immunodeficiency virus |
| 10090 | Mus musculus |
| 9986 | Oryctolagus cuniculus |
| 10114 | Rattus |
Consortium for Functional Glycomics (CFG):
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